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dc.contributor.authorZhang, Wen_US
dc.contributor.authorCline, MAen_US
dc.contributor.authorGilbert, ERen_US
dc.date.accessioned2017-01-06T15:49:17Z
dc.date.available2017-01-06T15:49:17Z
dc.date.issued2014-06-10en_US
dc.identifier.issn1743-7075en_US
dc.identifier.urihttp://hdl.handle.net/10919/73994
dc.description.abstractNeuropeptide Y (NPY) is an orexigenic neuropeptide that plays a role in regulating adiposity by promoting energy storage in white adipose tissue and inhibiting brown adipose tissue activation in mammals. This review describes mechanisms underlying NPY’s effects on adipose tissue energy metabolism, with an emphasis on cellular proliferation, adipogenesis, lipid deposition, and lipolysis in white adipose tissue, and brown fat activation and thermogenesis. In general, NPY promotes adipocyte differentiation and lipid accumulation, leading to energy storage in adipose tissue, with effects mediated mainly through NPY receptor sub-types 1 and 2. This review highlights hypothalamus-sympathetic nervous system-adipose tissue innervation and adipose tissue-hypothalamus feedback loops as pathways underlying these effects. Potential sources of NPY that mediate adipose effects include the bloodstream, sympathetic nerve terminals that innervate the adipose tissue, as well as adipose tissue-derived cells. Understanding the role of central vs. peripherally-derived NPY in whole-body energy balance could shed light on mechanisms underlying the pathogenesis of obesity. This information may provide some insight into searching for alternative therapeutic strategies for the treatment of obesity and associated diseases.
dc.format.extent? - ? (12) page(s)en_US
dc.languageEnglishen_US
dc.publisherBiomed Central Ltden_US
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000338242000001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en_US
dc.rightsCreative Commons Attribution 4.0 International (CC BY 4.0)*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectNutrition & Dieteticsen_US
dc.subjectAdipose tissueen_US
dc.subjectHypothalamusen_US
dc.subjectneuropeptide Yen_US
dc.subjectObesityen_US
dc.subjectSympathetic nervous systemen_US
dc.subjectThermogenesisen_US
dc.subjectRECEPTOR ANTISENSE OLIGODEOXYNUCLEOTIDESen_US
dc.subjectSPONTANEOUS FOOD-INTAKEen_US
dc.subjectDIET-INDUCED OBESITYen_US
dc.subjectNERVOUS-SYSTEMen_US
dc.subjectBODY-WEIGHTen_US
dc.subjectADIPOCYTE PROLIFERATIONen_US
dc.subjectSYMPATHETIC ACTIVITYen_US
dc.subjectSENSORY DENERVATIONen_US
dc.subjectLIPID-ACCUMULATIONen_US
dc.subjectMURINE ADIPOCYTESen_US
dc.titleHypothalamus-adipose tissue crosstalk: neuropeptide Y and the regulation of energy metabolismen_US
dc.typeArticle - Refereed
dc.typeReview
dc.description.versionPublished (Publication status)en_US
dc.title.serialNUTRITION & METABOLISMen_US
dc.identifier.doihttps://doi.org/10.1186/1743-7075-11-27
dc.identifier.volume11en_US
dc.type.dcmitypeText
pubs.organisational-group/Virginia Tech
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/Animal and Poultry Sciences
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/CALS T&R Faculty
pubs.organisational-group/Virginia Tech/All T&R Faculty
pubs.organisational-group/Virginia Tech/Faculty of Health Sciences


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Creative Commons Attribution 4.0 International (CC BY 4.0)
License: Creative Commons Attribution 4.0 International (CC BY 4.0)