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dc.contributor.authorZhang, Wen_US
dc.contributor.authorCline, MAen_US
dc.contributor.authorLiu, Den_US
dc.contributor.authorGilbert, ERen_US
dc.coverage.spatialUnited Statesen_US
dc.date.accessioned2017-01-06T15:49:43Z
dc.date.available2017-01-06T15:49:43Z
dc.date.issued2013-10-01en_US
dc.identifier.issn2162-3945en_US
dc.identifier.urihttp://hdl.handle.net/10919/73995
dc.description.abstractZBED6 was identified as a transcription factor that affects muscle mass and fat deposition in pigs. Mechanisms mediating effects on fat mass are unclear. The objective was to determine the effect of ZBED6 mRNA knockdown on 3T3-L1 preadipocyte differentiation and gene expression. Differentiation was associated with increased mRNA abundance of CEBP/α (P < 0.05), CEBP/β (P < 0.05), CEBP/δ (P < 0.05), FASN (P < 0.05), PPARγ (P < 0.05), and SREBP-1 (P < 0.05), and decreased abundance of PREF-1 (P < 0.05). Knockdown of ZBED6 was not associated with changes in mRNA abundance of selected genes, lipid accumulation, lipid droplet size, or cell number. These results suggest that ZBED6 does not play a major role in preadipocyte differentiation.en_US
dc.format.extent251 - 255 page(s)en_US
dc.languageengen_US
dc.relation.urihttp://www.ncbi.nlm.nih.gov/pubmed/24052901en_US
dc.rightsCreative Commons Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0)*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/*
dc.subject3T3-L1en_US
dc.subjectIGF2en_US
dc.subjectRNAien_US
dc.subjectZBED6en_US
dc.subjectadipogenesisen_US
dc.subjectproliferationen_US
dc.titleKnockdown of ZBED6 is not associated with changes in murine preadipocyte proliferation or differentiation.en_US
dc.typeArticle - Refereed
dc.description.versionPublished (Publication status)en_US
dc.rights.holderThe Author(s)en_US
dc.title.serialAdipocyteen_US
dc.identifier.doihttps://doi.org/10.4161/adip.26028
dc.identifier.volume2en_US
dc.identifier.issue4en_US
pubs.organisational-group/Virginia Tech
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/Animal and Poultry Sciences
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/CALS T&R Faculty
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/Human Nutrition, Foods, & Exercise
pubs.organisational-group/Virginia Tech/All T&R Faculty
pubs.organisational-group/Virginia Tech/Faculty of Health Sciences


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Creative Commons Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0)
License: Creative Commons Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0)