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dc.contributor.authorSanz Fernandez, M. V.en_US
dc.contributor.authorStoakes, S. K.en_US
dc.contributor.authorAbuajamieh, M.en_US
dc.contributor.authorSeibert, J. T.en_US
dc.contributor.authorJohnson, J. S.en_US
dc.contributor.authorHorst, E. A.en_US
dc.contributor.authorRhoads, R. P.en_US
dc.contributor.authorBaumgard, L. H.en_US
dc.coverage.spatialUnited Statesen_US
dc.description.abstractProper insulin homeostasis appears critical for adapting to and surviving a heat load. Further, heat stress (HS) induces phenotypic changes in livestock that suggest an increase in insulin action. The current study objective was to evaluate the effects of HS on whole-body insulin sensitivity. Female pigs (57 ± 4 kg body weight) were subjected to two experimental periods. During period 1, all pigs remained in thermoneutral conditions (TN; 21°C) and were fed ad libitum. During period 2, pigs were exposed to: (i) constant HS conditions (32°C) and fed ad libitum (n = 6), or (ii) TN conditions and pair-fed (PFTN; n = 6) to eliminate the confounding effects of dissimilar feed intake. A hyperinsulinemic euglycemic clamp (HEC) was conducted on d3 of both periods; and skeletal muscle and adipose tissue biopsies were collected prior to and after an insulin tolerance test (ITT) on d5 of period 2. During the HEC, insulin infusion increased circulating insulin and decreased plasma C-peptide and nonesterified fatty acids, similarly between treatments. From period 1 to 2, the rate of glucose infusion in response to the HEC remained similar in HS pigs while it decreased (36%) in PFTN controls. Prior to the ITT, HS increased (41%) skeletal muscle insulin receptor substrate-1 protein abundance, but did not affect protein kinase B or their phosphorylated forms. In adipose tissue, HS did not alter any of the basal or stimulated measured insulin signaling markers. In summary, HS increases whole-body insulin-stimulated glucose uptake.en_US
dc.rightsIn Copyrighten
dc.subjectHeat Stressen_US
dc.subjectinsulin sensitivityen_US
dc.titleHeat stress increases insulin sensitivity in pigsen_US
dc.typeArticle - Refereed
dc.description.versionPublished (Publication status)en_US
dc.contributor.departmentAnimal and Poultry Sciencesen_US
dc.title.serialPhysiological Reportsen_US
pubs.organisational-group/Virginia Tech
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/Animal and Poultry Sciences
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/CALS T&R Faculty
pubs.organisational-group/Virginia Tech/All T&R Faculty
pubs.organisational-group/Virginia Tech/Faculty of Health Sciences

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