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dc.contributor.authorHu, Yunen_US
dc.contributor.authorEhrich, Marionen_US
dc.contributor.authorFuhrman, Kristelen_US
dc.contributor.authorZhang, Chenmingen_US
dc.date.accessioned2017-01-15T15:19:37Z
dc.date.available2017-01-15T15:19:37Z
dc.date.issued2014-08-27en_US
dc.identifier.citationNanoscale Research Letters. 2014 Aug 27;9(1):434
dc.identifier.issn1556-276Xen_US
dc.identifier.urihttp://hdl.handle.net/10919/74319
dc.description.abstractDue to the many beneficial properties combined from both poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) and liposomes, lipid-PLGA hybrid NPs have been intensively studied as cancer drug delivery systems, bio-imaging agent carriers, as well as antigen delivery vehicles. However, the impact of lipid composition on the performance of lipid-PLGA hybrid NPs as a delivery system has not been well investigated. In this study, the influence of lipid composition on the stability of the hybrid NPs and in vitro antigen release from NPs under different conditions was examined. The uptake of hybrid NPs with various surface charges by dendritic cells (DCs) was carefully studied. The results showed that PLGA NPs enveloped by a lipid shell with more positive surface charges could improve the stability of the hybrid NPs, enable better controlled release of antigens encapsulated in PLGA NPs, as well as enhance uptake of NPs by DC.
dc.format.extent? - ? (10) page(s)en_US
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.publisherSpringeren_US
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000341882500001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en_US
dc.rightsCreative Commons Attribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectTechnologyen_US
dc.subjectNanoscience & Nanotechnologyen_US
dc.subjectMaterials Science, Multidisciplinaryen_US
dc.subjectPhysics, Applieden_US
dc.subjectScience & Technology - Other Topicsen_US
dc.subjectMaterials Scienceen_US
dc.subjectPhysicsen_US
dc.subjectHybrid NPen_US
dc.subjectLipid compositionen_US
dc.subjectPLGAen_US
dc.subjectSurface chargeen_US
dc.subjectVaccineen_US
dc.subjectAntigen deliveryen_US
dc.subjectHUMAN DENDRITIC CELLSen_US
dc.subjectDRUG-DELIVERYen_US
dc.subjectRELEASE PROFILESen_US
dc.subjectLIPOSOMESen_US
dc.subjectPLATFORMen_US
dc.subjectSIZEen_US
dc.titleIn vitro performance of lipid-PLGA hybrid nanoparticles as an antigen delivery system: lipid composition mattersen_US
dc.typeArticle - Refereed
dc.description.versionPublished (Publication status)en_US
dc.rights.holderYun Hu et al.; licensee BioMed Central Ltd.
dc.title.serialNANOSCALE RESEARCH LETTERSen_US
dc.identifier.doihttps://doi.org/10.1186/1556-276X-9-434
dc.identifier.volume9en_US
dc.type.dcmitypeText
pubs.organisational-group/Virginia Tech
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/Biological Systems Engineering
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/CALS T&R Faculty
pubs.organisational-group/Virginia Tech/All T&R Faculty
pubs.organisational-group/Virginia Tech/Faculty of Health Sciences
pubs.organisational-group/Virginia Tech/Veterinary Medicine
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Biomedical Sciences and Pathobiology
pubs.organisational-group/Virginia Tech/Veterinary Medicine/CVM T&R Faculty


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Creative Commons Attribution 4.0 International
License: Creative Commons Attribution 4.0 International