Show simple item record

dc.contributor.authorCheng, Zhiyong
dc.contributor.authorAlmeida, Fabio A.
dc.date.accessioned2017-02-15T19:12:03Z
dc.date.available2017-02-15T19:12:03Z
dc.date.issued2014-03-15
dc.identifier.urihttp://hdl.handle.net/10919/75046
dc.description.abstractThe growing epidemic of type 2 diabetes mellitus (T2DM) and obesity is largely attributed to the current lifestyle of over-consumption and physical inactivity. As the primary platform controlling metabolic and energy homeostasis, mitochondria show aberrant changes in T2DM and obese subjects. While the underlying mechanism is under extensive investigation, epigenetic regulation is now emerging to play an important role in mitochondrial biogenesis, function, and dynamics. In line with lifestyle modifications preventing mitochondrial alterations and metabolic disorders, exercise has been shown to change DNA methylation of the promoter of PGC1α to favor gene expression responsible for mitochondrial biogenesis and function. In this article we discuss the epigenetic mechanism of mitochondrial alteration in T2DM and obesity, and the effects of lifestyle on epigenetic regulation. Future studies designed to further explore and integrate the epigenetic mechanisms with lifestyle modification may lead to interdisciplinary interventions and novel preventive options for mitochondrial alteration and metabolic disorders.en_US
dc.format.mimetypeapplication/pdfen_US
dc.language.isoen_USen_US
dc.publisherLandes Bioscienceen_US
dc.rightsCreative Commons Attribution-NonCommercial 3.0 United States (CC BY-NC 3.0 US)*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/*
dc.subjectmitochondrial alterationen_US
dc.subjectepigeneticen_US
dc.subjecttype 2 diabetesen_US
dc.subjectobesityen_US
dc.subjectlifestyleen_US
dc.titleMitochondrial alteration in type 2 diabetes and obesityen_US
dc.typeArticle - Refereeden_US
dc.title.serialCell Cycleen_US
dc.identifier.doihttps://doi.org/10.4161/cc.28189
dc.identifier.volume13en_US
dc.identifier.issue6en_US
dc.type.dcmitypeTexten_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Creative Commons Attribution-NonCommercial 3.0 United States (CC BY-NC 3.0 US)
License: Creative Commons Attribution-NonCommercial 3.0 United States (CC BY-NC 3.0 US)