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dc.contributor.authorPoranki, Den_US
dc.contributor.authorGoodwin, Cen_US
dc.contributor.authorVan Dyke, Men_US
dc.date.accessioned2017-03-01T16:03:45Z
dc.date.available2017-03-01T16:03:45Z
dc.date.issued2016-01-01en_US
dc.identifier.citationD. Poranki, C. Goodwin, and M. Van Dyke, “Assessment of Deep Partial Thickness Burn Treatment with Keratin Biomaterial Hydrogels in a Swine Model,” BioMed Research International, vol. 2016, Article ID 1803912, 10 pages, 2016. doi:10.1155/2016/1803912
dc.identifier.issn2314-6133en_US
dc.identifier.urihttp://hdl.handle.net/10919/75206
dc.description.abstractPartial thickness burns can advance to full thickness after initial injury due to inadequate tissue perfusion and increased production of inflammatory cytokines, which has been referred to as burn wound progression. In previous work, we demonstrated that a keratin biomaterial hydrogel appeared to reduce burn wound progression. In the present study, we tested the hypothesis that a modified keratin hydrogel could reduce burn wound progression and speed healing. Standardized burn wounds were created in Yorkshire swine and treated within 30 minutes with keratin hydrogel (modified and unmodified), collagen hydrogel, or silver sulfadiazine (SSD). Digital images of each wound were taken for area measurements immediately prior to cleaning and dressing changes. Wound tissue was collected and assessed histologically at several time points. Wound area showed a significant difference between hydrogels and SSD groups, and rates of reepithelialization at early time points showed an increase when keratin treatment was used compared to both collagen and SSD. A linear regression model predicted a time to wound closure of approximately 25 days for keratin hydrogel while SSD treatment required 35 days. There appeared to be no measurable differences between the modified and unmodified formulations of keratin hydrogels.en_US
dc.format.extent? - ? (10) page(s)en_US
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.publisherHindawi Publishing Corpen_US
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000389929700001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en_US
dc.rightsCreative Commons Attribution 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectBiotechnology & Applied Microbiologyen_US
dc.subjectMedicine, Research & Experimentalen_US
dc.subjectResearch & Experimental Medicineen_US
dc.subjectTHROMBIN PEPTIDEen_US
dc.subjectSILVER SULFADIAZINEen_US
dc.subjectENDOTHELIAL-CELLSen_US
dc.subjectTHERMAL-STRESSen_US
dc.subjectIN-VITROen_US
dc.subjectTP508en_US
dc.subjectPATHWAYen_US
dc.subjectHAIRen_US
dc.titleAssessment of Deep Partial Thickness Burn Treatment with Keratin Biomaterial Hydrogels in a Swine Modelen_US
dc.typeArticle - Refereed
dc.description.versionPublished (Publication status)en_US
dc.rights.holderCopyright © 2016 D. Poranki et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.title.serialBIOMED RESEARCH INTERNATIONALen_US
dc.identifier.doihttps://doi.org/10.1155/2016/1803912
pubs.organisational-group/Virginia Tech
pubs.organisational-group/Virginia Tech/All T&R Faculty
pubs.organisational-group/Virginia Tech/Engineering
pubs.organisational-group/Virginia Tech/Engineering/Biomedical Engineering and Mechanics
pubs.organisational-group/Virginia Tech/Engineering/COE T&R Faculty
pubs.organisational-group/Virginia Tech/Faculty of Health Sciences


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Creative Commons Attribution 4.0 International
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