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dc.contributor.authorRamirez, Melissa V.en_US
dc.date.accessioned2017-04-06T15:43:21Z
dc.date.available2017-04-06T15:43:21Z
dc.date.issued2008-08-06en_US
dc.identifier.otheretd-08202008-083814en_US
dc.identifier.urihttp://hdl.handle.net/10919/77167
dc.description.abstractThe organization of metabolism is an essential feature of cellular biochemistry. Metabolism does not occur as a linear assembly of freely diffusing enzymes, but as a complex web in which multiple interactions are possible. Because of the crowded environment of the cell, there must be structured and ordered mechanisms that control metabolic pathways. The following work will examine two metabolic pathways, one that is ubiquitous among living organisms and another that is entirely unique to plants, and examine the organization of each in an attempt to further define mechanisms that are fundamental features of metabolic control. One study offers some of the first characterizations of genes involved in [Fe-S] cluster assembly in Arabidopsis. The other explores the mechanisms that control localization of an enzyme that is part of the well-characterized flavonoid biosynthetic pathway. These two distinct pathways serve as unique models for genetic and biochemical studies that contribute to our overall understanding of plant metabolism.
dc.language.isoen_USen_US
dc.publisherVirginia Techen_US
dc.rightsI hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Virginia Tech or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report.en_US
dc.subjectintracellular localizationen_US
dc.subjectchalcone synthaseen_US
dc.subject[Fe-S] cluster assemblyen_US
dc.subjectflavonoid biosynthesisen_US
dc.subjectconfocal microscopyen_US
dc.titleProbing Plant Metabolism: The Machineries of [Fe-S] Cluster Assembly and Flavonoid Biosynthesisen_US
dc.typeDissertationen_US
dc.contributor.departmentBiologyen_US
dc.description.degreePh. D.en_US
thesis.degree.namePh. D.en_US
thesis.degree.leveldoctoralen_US
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen_US
dc.contributor.committeechairWinkel, Brenda S. J.en_US
dc.contributor.committeememberMcDowell, John M.en_US
dc.contributor.committeememberDean, Dennis R.en_US
dc.contributor.committeememberTholl, Dorothea B. C.en_US
dc.contributor.committeememberSible, Jill C.en_US
dc.type.dcmitypeTexten_US
dc.identifier.sourceurlhttp://theses.lib.vt.edu/theses/available/etd-08202008-083814/en_US
dc.date.sdate2008-08-20en_US
dc.date.rdate2016-10-17
dc.date.adate2008-09-12en_US


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