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dc.contributor.authorPan, Endeen_US
dc.date.accessioned2017-04-06T15:44:13Z
dc.date.available2017-04-06T15:44:13Z
dc.date.issued2010-12-08en_US
dc.identifier.otheretd-01192011-120118en_US
dc.identifier.urihttp://hdl.handle.net/10919/77260
dc.description.abstractIn our continuing search for biologically active natural products from Madagascar as part of an International Cooperative Biodiversity Group (ICBG) program, a total of four antiproliferative extracts were studied, leading to the isolation of twelve novel compounds with antiproliferative activity against the A2780 human ovarian cancer line, and one extract with antimalarial activities was studied, which led to the isolation of five new natural products with antimalarial activities against the Dd2 and HB3 malarial parasites. The plants and their metabolites are discussed in the following order: one new xanthone and two known guttiferones from Symphonia tanalensis Jum. & H. Perrier (Clusiaceae); four new diphenyl propanes and one new cyclohepta-dibenzofuran skeleton from Bussea sakalava (Fabaceae); four new cardiac glycosides from Leptadenia madagascariensis Decne. (Apocynaceae); two new and four known alkaloids from Ambavia gerrardii (Baill.) Le Thomas (Annonaceae); five new sesquiterpene lactones from Polycline proteiformis Humbert (Asteraceae). The structures of all compounds were determined by analysis of their mass spectrometric, 1D and 2D NMR, UV and IR spectroscopic and optical rotation data. Other than structure elucidation, this dissertation also involve bioactivity evaluation of all the isolates, synthesis of two interesting alkaloids, as well as a proposal for the possible biosynthetic pathway of the new cyclohepta-dibenzofuran skeleton.
dc.language.isoen_USen_US
dc.publisherVirginia Techen_US
dc.rightsI hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Virginia Tech or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report.en_US
dc.subjectSesquiterpene lactoneen_US
dc.subjectAlkaloiden_US
dc.subjectDiphenylpropaneen_US
dc.subjectNatural Productsen_US
dc.subjectAnticanceren_US
dc.subjectAntimalarialen_US
dc.subjectAntiproliferativeen_US
dc.subjectFlavonoiden_US
dc.subjectCardenolideen_US
dc.titleSearching for Anticancer Agents and Antimalarial Agents from Madagascaren_US
dc.typeDissertationen_US
dc.contributor.departmentChemistryen_US
dc.description.degreePh. D.en_US
thesis.degree.namePh. D.en_US
thesis.degree.leveldoctoralen_US
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen_US
thesis.degree.disciplineChemistryen_US
dc.contributor.committeechairKingston, David G. I.en_US
dc.contributor.committeememberHanson, Brian E.en_US
dc.contributor.committeememberGibson, Harry W.en_US
dc.contributor.committeememberCarlier, Paul R.en_US
dc.contributor.committeememberTanko, James M.en_US
dc.type.dcmitypeTexten_US
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-01192011-120118/en_US
dc.date.sdate2011-01-19en_US
dc.date.rdate2016-10-17
dc.date.adate2011-02-01en_US


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