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dc.contributor.authorWynn, Jessica E.
dc.contributor.authorZhang, Wenyu
dc.contributor.authorTebit, Denis M.
dc.contributor.authorGray, Laurie R.
dc.contributor.authorHammarskjold, Marie-Louise
dc.contributor.authorRekosh, David
dc.contributor.authorSantos, Webster L.
dc.date.accessioned2017-05-01T06:42:18Z
dc.date.available2017-05-01T06:42:18Z
dc.date.issued2016-06-06
dc.identifierc6md00171h.pdf
dc.identifierc6md00171h1.pdf
dc.identifierc6md00171h2.zip
dc.identifier.issn2040-2503
dc.identifier.urihttp://hdl.handle.net/10919/77562
dc.description.abstractHigh throughput screening of a 4096 compound library of boronic acid and acridine containing branched peptides revealed compounds that have dissociation constants in the low nanomolar regime for HIV-1 RRE IIB RNA. We demonstrate that branched peptide boronic acids A5, A6, and A7 inhibit the production of p24, an HIV-1 capsid protein, in a dose-dependent manner.
dc.format.extent1436-1440
dc.format.mimetypeapplication/pdf
dc.format.mimetypeapplication/zip
dc.language.isoen_US
dc.publisherRoyal Society of Chemistry
dc.relation.ispartofRoyal Society of Chemistry Gold Open Access - 2016
dc.rightsCC BY-NC 3.0
dc.rightsCreative Commons Attribution-NonCommercial 3.0 Unported
dc.rights.urihttps://creativecommons.org/licenses/by-nc/3.0/
dc.titleEffect of intercalator and Lewis acid-base branched peptide complex formation: boosting affinity towards HIV-1 RRE RNA
dc.typeArticle - Refereed
dc.rights.holderWynn, Jessica E.
dc.rights.holderZhang, Wenyu
dc.rights.holderTebit, Denis M.
dc.rights.holderGray, Laurie R.
dc.rights.holderHammarskjold, Marie-Louise
dc.rights.holderRekosh, David
dc.rights.holderSantos, Webster L.
dc.contributor.departmentVirginia Tech. Department of Chemistry
dc.contributor.departmentVirginia Tech. Center for Drug Discovery
dc.title.serialMedicinal Chemical Communications
dc.identifier.doihttps://doi.org/10.1039/c6md00171h
dc.identifier.volume7
dc.identifier.issue7
dc.type.dcmitypeText
dc.type.dcmitypeDataset
dc.identifier.eissn2040-2511


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License: CC BY-NC 3.0