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dc.contributor.authorFinno, CJen_US
dc.contributor.authorEstell, KEen_US
dc.contributor.authorKatzman, Sen_US
dc.contributor.authorWinfield, Len_US
dc.contributor.authorRendahl, Aen_US
dc.contributor.authorTextor, Jen_US
dc.contributor.authorBannasch, DLen_US
dc.contributor.authorPuschner, Ben_US
dc.coverage.spatialUnited Statesen_US
dc.date.accessioned2017-05-09T19:59:11Z
dc.date.available2017-05-09T19:59:11Z
dc.date.issued2015-11en_US
dc.identifier.urihttp://hdl.handle.net/10919/77598
dc.description.abstractBACKGROUND: Equine neuroaxonal dystrophy/equine degenerative myeloencephalopathy (NAD/EDM) is a neurodegenerative disorder affecting genetically predisposed foals maintained on α-tocopherol (α-TP)-deficient diet. OBJECTIVE: Intramuscular α-TP and selenium (Se) administration at 4 days of age would have no significant effect on serum or cerebrospinal fluid (CSF) α-TP in healthy foals. Serum and CSF α-TP, but not Se, would be significantly decreased in NAD/EDM-affected foals during first year of life. ANIMALS: Fourteen Quarter horse foals; 10 healthy foals supplemented with 0.02 mL/kg injectable α-TP and Se (n = 5) or saline (n = 5) at 4 days of age and 4 unsupplemented NAD/EDM-affected foals. METHODS: Complete neurologic examinations were performed, blood and CSF were collected before (4 days of age) and after supplementation at 10, 30, 60, 120, 180, 240, and 360 days of age. Additional blood collections occurred at 90, 150, 210, and 300 days. At 540 days, NAD/EDM-affected foals and 1 unsupplemented healthy foal were euthanized and necropsies performed. RESULTS: Significant decreases in blood, CSF α-TP and Se found in the first year of life in all foals, with most significant changes in serum α-TP from 4-150 days. Dam α-TP and Se significantly influenced blood concentrations in foals. Injection of α-TP and Se did not significantly increase CSF Se, blood or CSF α-TP in healthy foals. NAD/EDM-affected foals had significantly lower CSF α-TP through 120 days. CONCLUSIONS AND CLINICAL IMPORTANCE: Injection of α-TP and Se at 4 days of age does not significantly increase blood or CSF α-TP. Despite all 14 foals remaining deficient in α-TP, only the 4 genetically predisposed foals developed NAD/EDM.en_US
dc.format.extent1667 - 1675 page(s)en_US
dc.languageengen_US
dc.relation.urihttp://www.ncbi.nlm.nih.gov/pubmed/26391904en_US
dc.rightsCreative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectAtaxiaen_US
dc.subjectEquineen_US
dc.subjectGeneticsen_US
dc.subjectVitamin Een_US
dc.subjectAnimalsen_US
dc.subjectAnimals, Newbornen_US
dc.subjectFemaleen_US
dc.subjectGenetic Predisposition to Diseaseen_US
dc.subjectHorse Diseasesen_US
dc.subjectHorsesen_US
dc.subjectMaleen_US
dc.subjectNeuroaxonal Dystrophiesen_US
dc.subjectSeleniumen_US
dc.subjectalpha-Tocopherolen_US
dc.titleBlood and Cerebrospinal Fluid α-Tocopherol and Selenium Concentrations in Neonatal Foals with Neuroaxonal Dystrophy.en_US
dc.typeArticle - Refereed
dc.description.versionPublished (Publication status)en_US
dc.rights.holderThe Author(s)en_US
dc.title.serialJ Vet Intern Meden_US
dc.identifier.doihttps://doi.org/10.1111/jvim.13618
dc.type.otherResearch Support, N.I.H., Extramuralen_US
dc.type.otherResearch Support, Non-U.S. Gov'ten_US
dc.identifier.volume29en_US
dc.identifier.issue6en_US
dc.identifier.orcidEstell, KE [0000-0002-9321-1952]en_US
dc.identifier.eissn1939-1676en_US
pubs.organisational-group/Virginia Tech
pubs.organisational-group/Virginia Tech/Veterinary Medicine
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Equine Medical Center


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Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
License: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)