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dc.contributor.authorBalhouse, Brittany Nicoleen
dc.date.accessioned2017-06-13T08:00:19Zen
dc.date.available2017-06-13T08:00:19Zen
dc.date.issued2017-06-12en
dc.identifier.othervt_gsexam:11306en
dc.identifier.urihttp://hdl.handle.net/10919/78027en
dc.description.abstractThe tumor microenvironment is a well-recognized contributor to cancer progression in solid tumors. Cancer cell interactions with abnormal extracellular matrix, tumor associated immune and stromal cells, and aberrant fluid flow all contribute to cancer progression. Breast tumors are often characterized by a dense collagenous stroma and a hypoxic core. A recently identified and little understood component of the breast tumor microenvironment is the breast microbiome. The work described here elaborates on the importance of the tumor microenvironment in cancer progression and demonstrates the importance of studying cancer-microbiome interactions in the context of tumor microenvironmental stimuli.en
dc.format.mediumETDen
dc.publisherVirginia Techen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectN-(3-oxododecanoyl)-L-homoserine lactoneen
dc.subjectbreast canceren
dc.subjectmicrobiomeen
dc.subjecttissue engineeringen
dc.subjecttumor microenvironmenten
dc.subjectin vitroen
dc.titleN-(3-Oxododecanoyl)-L-Homoserine Lactone in the Breast Tumor Microenvironmenten
dc.typeThesisen
dc.contributor.departmentBiomedical Engineeringen
dc.description.degreeMaster of Scienceen
thesis.degree.nameMaster of Scienceen
thesis.degree.levelmastersen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.disciplineBiomedical Engineeringen
dc.contributor.committeechairVerbridge, Scotten
dc.contributor.committeememberSchmelz, Eva M.en
dc.contributor.committeememberDavalos, Rafael V.en
dc.contributor.committeememberSlade, Daniel J.en


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