Evidence of Executive Dysfunction in Co-occurring Substance Use Disorder and Major Depressive Disorder or Antisocial Personality Disorder
MetadataShow full item record
Background and Aims: Executive dysfunction is pervasive in substance-dependent individuals (Verdejo-GarcÃa, Bechara, Recknor, & Perez-Garcia, 2006). As many as four-fifths of individuals in treatment for substance use disorders (SUDs) have co-existing lifetime psychopathology. Executive function deficits are tied to markers of decreased quality of life including increases in negative life events (Green, Kern, Braff, & Mintz, 2000), maladaptive social functioning (Kurtz, Moberg, Ragland, Gur, & Gur, 2005) and worsened treatment outcomes (Czuchry & Dansereau, 2003). Despite evidence of executive dysfunction across several mental disorders, few studies investigate how the co-occurrence of psychopathologies in SUDs impacts executive functioning. Methods: Here, we compare measures of executive function (i.e., the Iowa Gambling Test, Letter Number Sequencing Test, Stroop Test, Wisconsin Card Sorting Test, Continuous Performance Test, Towers Test, and Delay Discounting Test) in individuals with a) substance use disorder, b) substance use disorder and co-occurring major depressive disorder, c) substance use disorder and co-occurring antisocial personality disorder, d) substance use disorder and co-occurring major depressive disorder and antisocial personality disorder and e) no substance use disorder or co-occurring psychopathology. Results: Regression models of respective executive function measure outcomes as a function of education, income, age, and group membership indicated that the Delay Discounting Test and Continuous Performance Test were the only significant overall models (F(4, 313) = 12.699, p < 0.001 and F(4, 307) = 2.659, p = 0.033, respectively). Conclusions: Overall the Delay Discounting Test and Continuous Performance Test were the most sensitive to differences between substance use and psychopathology profiles assessed.
- Masters Theses 
Showing items related by title, author, creator and subject.
Externalizing problems, attention regulation, and household chaos: A longitudinal behavioral genetic study Wang, Z.; Deater-Deckard, Kirby; Petrill, S. A.; Thompson, L. A. (Cambridge University Press, 2012-08)Previous research documented a robust link between difficulties in self-regulation and development of externalizing problems (i.e., aggression and delinquency). In this study, we examined the longitudinal additive and ...
Challenges and Strengths of College Students with Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder Elias, Rebecca M. (Virginia Tech, 2015-12-10)Emerging adults who have Autism Spectrum Disorder (ASD) often encounter difficulties within the university setting. Despite an increase in the number of students with ASD enrolled in postsecondary educational institutions, ...
A Cross-Cultural Comparisons of Factors Related to Help-Seeking Attitudes for Psychological Disorder Hirai, Michiyo (Virginia Tech, 1999-04-19)It has been reported that Asian people have negative views of mental illness, including beliefs that it is incurable and shameful. Asian people also tend to attribute causes of mental disorders to factors less susceptible ...