Now showing items 21-40 of 1805

    • A human exposome framework for guiding risk management and holistic assessment of recycled water quality 

      Garner, Emily; Zhu, Ni; Strom, Laurel; Edwards, Marc A.; Pruden, Amy (Royal Society of Chemistry, 2016-04-12)
      Challenges associated with water scarcity and increasing water demand are leading many cities around the globe to consider water reuse as a step towards water sustainability. Recycled water may be used in a spectrum of ...
    • A Model for a Smallpox-Vaccination Policy 

      Bozzette, Samuel A.; Boer, Rob; Bhatnagar, Vibha; Brower, Jennifer L.; Keeler, Emmett B.; Morton, Sally C.; Stoto, Michael A. (NEJM Group, 2003-01-30)
      Background: The new reality of biologic terrorism and warfare has ignited a debate about whether to reintroduce smallpox vaccination. Methods: We developed scenarios of smallpox attacks and built a stochastic model of ...
    • A Modest Proposal for Open Market Risk Assessment to Solve the Cyber-Security Problem 

      O’Shea, Timothy J.; Mondl, Adam; Clancy, T. Charles (Virginia Tech, 2016-04-29)
      We introduce a model for a market based economic system of cyber-risk valuation to correct fundamental problems of incentives within the information technology and information processing industries. We assess the makeup ...
    • A Molecular Mechanism Regulating the Timing of Corticogeniculate Innervation 

      Brooks, Justin M.; Su, Jianmin; Levy, Carl; Wang, Jessica S.; Seabrook, Tania A.; Guido, William (Elsevier, 2013-11-14)
      Neural circuit formation demands precise timing of innervation by different classes of axons. However, the mechanisms underlying such activity remain largely unknown. In the dorsal lateral geniculate nucleus (dLGN), axons ...
    • A Multi-Tier Wireless Spectrum Sharing System Leveraging Secure Spectrum Auctions 

      Abdelhadi, Ahmed; Shajaiah, Haya; Clancy, Charles (IEEE, 2015-10-08)
      Secure spectrum auctions can revolutionize the spectrum utilization of cellular networks and satisfy the ever increasing demand for resources. In this paper, a multi-tier dynamic spectrum sharing system is studied for ...
    • A Simulation Optimization Approach to Epidemic Forecasting 

      Nsoesie, Elaine O.; Beckman, Richard J.; Shashaani, Sara; Nagaraj, Kalyani S.; Marathe, Madhav V. (PLOS, 2013-06-27)
      Reliable forecasts of influenza can aid in the control of both seasonal and pandemic outbreaks. We introduce a simulation optimization (SIMOP) approach for forecasting the influenza epidemic curve. This study represents ...
    • A systematic review of studies on forecasting the dynamics of influenza outbreaks 

      Nsoesie, Elaine O.; Brownstein, John S.; Ramakrishnan, Naren; Marathe, Madhav V. (Wiley, 2013-12-23)
      Forecasting the dynamics of influenza outbreaks could be useful for decision-making regarding the allocation of public health resources. Reliable forecasts could also aid in the selection and implementation of interventions ...
    • A Workshop Conceptualizing Leadership 

      Maybaumwisniewsk, Susani; DiPasquantonio, Maria; Stern, Jeffrey D. (Center for Public Administration & Policy, School of Public & International Affairs, Virginia Polytechnic Institute and State University, 2007-07)
      The purpose of the Virginia Tech Center for Public Administration and Policy (CPAP) Roundtable Series for Leadership and Administration is to bring together the leading scholars, practitioners, students, and others for a ...
    • Aberrant Calcium Signaling in Astrocytes Inhibits Neuronal Excitability in a Human Down Syndrome Stem Cell Model 

      Mizuno, Grace O.; Wang, Yinxue; Shi, Guilai; Wang, Yizhi; Sun, Junqing; Papadopoulos, Stelios; Broussard, Gerard J.; Unger, Elizabeth K.; Deng, Wenbin; Weick, Jason; Bhattacharyya, Anita; Chen, Chao-Yin; Yu, Guoqiang; Looger, Loren L.; Tian, Lin (Elsevier, 2018-07-10)
      Down syndrome (DS) is a genetic disorder that causes cognitive impairment. The staggering effects associated with an extra copy of human chromosome 21 (HSA21) complicates mechanistic understanding of DS pathophysiology. ...
    • Aberrant early growth of individual trigeminal sensory and motor axons in a series of mouse genetic models of 22q11.2 deletion syndrome 

      Motahari, Zahra; Maynard, Thomas M.; Popratiloff, Anastas; Moody, Sally A.; LaMantia, Anthony-Samuel (2020-09-15)
      We identified divergent modes of initial axon growth that prefigure disrupted differentiation of the trigeminal nerve (CN V), a cranial nerve essential for suckling, feeding and swallowing (S/F/S), a key innate behavior ...
    • Abrogation of atypical neurogenesis and vascular-derived EphA4 prevents repeated mild TBI-induced learning and memory impairments 

      Greer, Kisha; Basso, Erwin Kristobal Gudenschwager; Kelly, Colin; Cash, Alison; Kowalski, Elizabeth; Cerna, Steven; Ocampo, Collin Tanchanco; Wang, Xia; Theus, Michelle H. (2020-09-21)
      Brain injury resulting from repeated mild traumatic insult is associated with cognitive dysfunction and other chronic co-morbidities. The current study tested the effects of aberrant neurogenesis in a mouse model of repeated ...
    • Access to Autism Spectrum Disorder Services for Rural Appalachian Citizens 

      Scarpa, Angela; Jensen, Laura S.; Gracanin, Denis; Ramey, Sharon L.; Dahiya, Angela V.; Ingram, L. Maria; Albright, Jordan; Gatto, Alyssa J.; Scott, Jen Pollard; Ruble, Lisa (2020-01)
      Background: Low-resource rural communities face significant challenges regarding availability and adequacy of evidence-based services. Purposes: With respect to accessing evidence-based services for Autism Spectrum ...
    • Acetylcholine Receptor Activation as a Modulator of Glioblastoma Invasion 

      Thompson, Emily G.; Sontheimer, Harald (MDPI, 2019-10-05)
      Grade IV astrocytomas, or glioblastomas (GBMs), are the most common malignant primary brain tumor in adults. The median GBM patient survival of 12–15 months has remained stagnant, in spite of treatment strategies, ...
    • Acoustic differences between healthy and depressed people: a cross-situation study 

      Wang, Jingying; Zhang, Lei; Liu, Tianli; Pan, Wei; Hu, Bin; Zhu, Tingshao (2019-10-15)
      Background Abnormalities in vocal expression during a depressed episode have frequently been reported in people with depression, but less is known about if these abnormalities only exist in special situations. In addition, ...
    • Active inference and agency: optimal control without cost functions 

      Friston, Karl; Samothrakis, Spyridon; Montague, P. Read (Springer, 2012-08-03)
      This paper describes a variational free-energy formulation of (partially observable) Markov decision problems in decision making under uncertainty. We show that optimal control can be cast as active inference. In active ...
    • Activity Dependent Protein Degradation Is Critical for the Formation and Stability of Fear Memory in the Amygdala 

      Jarome, Timothy J.; Werner, Craig T.; Kwapis, Janine L.; Helmstetter, Fred J. (PLOS, 2011-09)
      Protein degradation through the ubiquitin-proteasome system [UPS] plays a critical role in some forms of synaptic plasticity. However, its role in memory formation in the amygdala, a site critical for the formation of fear ...
    • An Adaptive Actuation Mechanism for Anthropomorphic Robot Hands 

      Kontoudis, George P.; Liarokapis, Minas; Vamvoudakis, Kyriakos G.; Furukawa, Tomonari (Frontiers, 2019-07-05)
      This paper presents an adaptive actuation mechanism that can be employed for the development of anthropomorphic, dexterous robot hands. The tendon-driven actuation mechanism achieves both flexion/extension and adduction/abduction ...
    • Adaptive Brain and Behavior Across the Lifespan 

      Unknown author (Virginia Tech, 2016-05)
      Our aim is to understand adaptation and improve human lives in various contexts. Inequalities and environments in which people live affect their health and behavior — and their success of remaining healthy for a lifetime. ...
    • Adaptive Key Protection in Complex Cryptosystems with Attributes 

      Wang, Zilong; Yao, Danfeng (Daphne); Feng, Rongquan (Department of Computer Science, Virginia Polytechnic Institute & State University, 2012), TR-12-16
      In the attribute-based encryption (ABE) model, attributes (as opposed to identities) are used to encrypt messages, and all the receivers with qualifying attributes can decrypt the ciphertext. However, compromised attribute ...