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DeepARG: a deep learning approach for predicting antibiotic resistance genes from metagenomic data
(2018-02-01)
Background
Growing concerns about increasing rates of antibiotic resistance call for expanded and comprehensive global monitoring. Advancing methods for monitoring of environmental media (e.g., wastewater, agricultural ...
Critical evaluation of short, long, and hybrid assembly for contextual analysis of antibiotic resistance genes in complex environmental metagenomes
(2021-02-12)
In the fight to limit the global spread of antibiotic resistance, the assembly of environmental metagenomes has the potential to provide rich contextual information (e.g., taxonomic hosts, carriage on mobile genetic elements) ...
Natural Organic Matter, Orthophosphate, pH, and Growth Phase Can Limit Copper Antimicrobial Efficacy for Legionella in Drinking Water
(2021-02-02)
Copper (Cu) is a promising antimicrobial for premise plumbing, where ions can be dosed directly via copper silver ionization or released naturally via corrosion of Cu pipes, but Cu sometimes inhibits and other times ...
Opportunistic Premise Plumbing Pathogens: Increasingly Important Pathogens in Drinking Water.
(MDPI, 2015-06-09)
Opportunistic premise plumbing pathogens are responsible for a significant number of infections whose origin has been traced to drinking water. These opportunistic pathogens represent an emerging water borne disease problem ...
Convective Mixing in Distal Pipes Exacerbates Legionella pneumophila Growth in Hot Water Plumbing.
(MDPI, 2016-03-12)
Legionella pneumophila is known to proliferate in hot water plumbing systems, but little is known about the specific physicochemical factors that contribute to its regrowth. Here, L. pneumophila trends were examined in ...
Translating research to policy at the NCSE 2017 symposium “Microbiology of the Built Environment: Implications for Health and Design”
(2018-09-15)
Here, we summarize a symposium entitled “Microbiology of the Built Environment: Implications for Health and Design” that was presented at the National Council for Science and the Environment (NCSE) 17th National Conference ...
NanoARG: a web service for detecting and contextualizing antimicrobial resistance genes from nanopore-derived metagenomes
(2019-06-07)
Background
Direct and indirect selection pressures imposed by antibiotics and co-selective agents and horizontal gene transfer are fundamental drivers of the evolution and spread of antibiotic resistance. ...
Identification of discriminatory antibiotic resistance genes among environmental resistomes using extremely randomized tree algorithm
(2019-08-29)
Background
The interconnectivities of built and natural environments can serve as conduits for the proliferation and dissemination of antibiotic resistance genes (ARGs). Several studies have compared the broad spectrum of ...
Critical Review: Propensity of Premise Plumbing Pipe Materials to Enhance or Diminish Growth of Legionella and Other Opportunistic Pathogens
(MDPI, 2020-11-17)
Growth of <i>Legionella pneumophila</i> and other opportunistic pathogens (OPs) in drinking water premise plumbing poses an increasing public health concern. Premise plumbing is constructed of a variety of materials, ...
Relationship between Organic Carbon and Opportunistic Pathogens in Simulated Glass Water Heaters
(MDPI, 2015-06-09)
Controlling organic carbon levels in municipal water has been hypothesized to limit downstream growth of bacteria and opportunistic pathogens in premise plumbing (OPPPs). Here, the relationships between influent organic ...