Now showing items 1-10 of 26
Connexin 43 peptidic medicine for glioblastoma stem cells
Prediction of condition-specific regulatory genes using machine learning
(Oxford University Press, 2020-06-19)
Recent advances in genomic technologies have generated data on large-scale protein–DNA interactions and open chromatin regions for many eukaryotic species. How to identify condition-specific functions of transcription ...
Thermal biology of mosquito-borne disease
Mosquito-borne diseases cause a major burden of disease worldwide. The vital rates of these ectothermic vectors and parasites respond strongly and nonlinearly to temperature and therefore to climate change. Here, we review ...
A selective sweep in the Spike gene has driven SARS-CoV-2 human adaptation
(Cell Press, 2021-08-19)
The coronavirus disease 2019 (COVID-19) pandemic underscores the need to better understand animal-to-human transmission of coronaviruses and adaptive evolution within new hosts. We scanned more than 182,000 severe acute ...
Water Safety in California Public Schools Following Implementation of School Drinking Water Policies
(Centers for Disease Control and Prevention, 2020-12-01)
Introduction: Recent legislation requires public and charter schools in California to test drinking water for lead. Our objective was to describe 1)results from this testing program in the context of other available water ...
Cyberbiosecurity Challenges of Pathogen Genome Databases
Pathogen detection, identification, and tracking is shifting from non-molecular methods, DNA fingerprinting methods, and single gene methods to methods relying on whole genomes. Viral Ebola and influenza genome data are ...
Pathology of non-thermal irreversible electroporation (N-TIRE)-induced ablation of the canine brain
(Korean Society of Veterinary Science, 2013-12-01)
This study describes the neuropathologic features of normal canine brain ablated with non-thermal irreversible electroporation (N-TIRE). The parietal cerebral cortices of four dogs were treated with N-TIRE using a ...
Processes linking socioeconomic disadvantage and neural correlates of cognitive control in adolescence
Socioeconomic status (SES) is broadly associated with self-regulatory abilities across childhood and adolescence. However, there is limited understanding of the mechanisms underlying this association, especially during ...
Delivery strategies for cell-based therapies in the brain: overcoming multiple barriers
Cell-based therapies to the brain are promising for the treatment of multiple brain disorders including neurodegeneration and cancers. In order to access the brain parenchyma, there are multiple physiological barriers that ...
Alzheimer's Disease-Like Neurodegeneration in Porphyromonas gingivalis Infected Neurons with Persistent Expression of Active Gingipains
(IOS Press, 2020-01-01)
Background: Porphyromonas gingivalis (P. gingivalis) and its gingipain virulence factors have been identified as pathogenic effectors in Alzheimer's disease (AD). In a recent study we demonstrated the presence of gingipains ...