Now showing items 1-10 of 26
Connexin 43 peptidic medicine for glioblastoma stem cells
Prediction of condition-specific regulatory genes using machine learning
(Oxford University Press, 2020-06-19)
Recent advances in genomic technologies have generated data on large-scale protein–DNA interactions and open chromatin regions for many eukaryotic species. How to identify condition-specific functions of transcription ...
Thermal biology of mosquito-borne disease
Mosquito-borne diseases cause a major burden of disease worldwide. The vital rates of these ectothermic vectors and parasites respond strongly and nonlinearly to temperature and therefore to climate change. Here, we review ...
A selective sweep in the Spike gene has driven SARS-CoV-2 human adaptation
(Cell Press, 2021-08-19)
The coronavirus disease 2019 (COVID-19) pandemic underscores the need to better understand animal-to-human transmission of coronaviruses and adaptive evolution within new hosts. We scanned more than 182,000 severe acute ...
Water Safety in California Public Schools Following Implementation of School Drinking Water Policies
(Centers for Disease Control and Prevention, 2020-12-01)
Introduction: Recent legislation requires public and charter schools in California to test drinking water for lead. Our objective was to describe 1)results from this testing program in the context of other available water ...
Delivery strategies for cell-based therapies in the brain: overcoming multiple barriers
Cell-based therapies to the brain are promising for the treatment of multiple brain disorders including neurodegeneration and cancers. In order to access the brain parenchyma, there are multiple physiological barriers that ...
Alzheimer's Disease-Like Neurodegeneration in Porphyromonas gingivalis Infected Neurons with Persistent Expression of Active Gingipains
(IOS Press, 2020-01-01)
Background: Porphyromonas gingivalis (P. gingivalis) and its gingipain virulence factors have been identified as pathogenic effectors in Alzheimer's disease (AD). In a recent study we demonstrated the presence of gingipains ...
Profiling nonhuman primate germline RNA to understand the legacy of early life stress
Exposure to stress is a risk factor for perturbed mental health, including impoverished regulation of emotional and physiological responses that accompany anxiety and mood disorders, substance abuse and behavioral disorders. ...
Prospective impact of COVID-19 on mental health functioning in adolescents with and without ADHD: protective role of emotion regulation abilities
Background: The impact of chronic stressors like the COVID-19 pandemic is likely to be magnified in adolescents with pre-existing mental health risk, such as attention-deficit/hyperactivity disorder (ADHD). This study ...
Synergistic China-US Ecological Research is Essential for Global Emerging Infectious Disease Preparedness
The risk of a zoonotic pandemic disease threatens hundreds of millions of people. Emerging infectious diseases also threaten livestock and wildlife populations around the world and can lead to devastating economic damages. ...