Now showing items 1-6 of 6

    • Aberrant Calcium Signaling in Astrocytes Inhibits Neuronal Excitability in a Human Down Syndrome Stem Cell Model 

      Mizuno, Grace O.; Wang, Yinxue; Shi, Guilai; Wang, Yizhi; Sun, Junqing; Papadopoulos, Stelios; Broussard, Gerard J.; Unger, Elizabeth K.; Deng, Wenbin; Weick, Jason; Bhattacharyya, Anita; Chen, Chao-Yin; Yu, Guoqiang; Looger, Loren L.; Tian, Lin (Elsevier, 2018-07-10)
      Down syndrome (DS) is a genetic disorder that causes cognitive impairment. The staggering effects associated with an extra copy of human chromosome 21 (HSA21) complicates mechanistic understanding of DS pathophysiology. ...
    • Aging into Perceptual Control: A Dynamic Causal Modeling for fMRI Study of Bistable Perception 

      Dowlati, Ehsan; Adams, Sarah E.; Stiles, Alexandra; Moran, Rosalyn J. (Frontiers, 2016-03-31)
      Aging is accompanied by stereotyped changes in functional brain activations, for example a cortical shift in activity patterns from posterior to anterior regions is one hallmark revealed by functional magnetic resonance ...
    • Automated Functional Analysis of Astrocytes from Chronic Time-Lapse Calcium Imaging Data 

      Wang, Yinxue; Shi, Guilai; Miller, David J.; Wang, Yizhi; Wang, Congchao; Broussard, Gerard; Wang, Yue; Tian, Lin; Yu, Goquiang (Frontiers, 2017-07-14)
      Recent discoveries that astrocytes exert proactive regulatory effects on neural information processing and that they are deeply involved in normal brain development and disease pathology have stimulated broad interest in ...
    • Circadian dynamics in measures of cortical excitation and inhibition balance 

      Chellappa, Sarah L.; Gaggioni, Giulia; Ly, Julien Q. M.; Papachilleos, Soterios; Borsu, Chloe; Brzozowski, Alexandre; Rosanova, Mario; Sarasso, Simone; Luxen, Andre; Middleton, Benita; Archer, Simon N.; Dijk, Derk-Jan; Massimini, Marcello; Maquet, Pierre; Phillips, Christophe; Moran, Rosalyn J.; Vandewalle, Gilles (Springer Nature, 2016-09-21)
      Several neuropsychiatric and neurological disorders have recently been characterized as dysfunctions arising from a 'final common pathway' of imbalanced excitation to inhibition within cortical networks. How the regulation ...
    • Dopamine Stimulates Propagation of Toxoplasma gondii Tachyzoites in Human Fibroblast and Primary Neonatal Rat Astrocyte Cell Cultures 

      Strobl, Jeannine S.; Goodwin, David G.; Rzigalinski, Beverly A.; Lindsay, David S. (American Society of Parasitology, 2012-12-01)
      Toxoplasma gondii is an obligate intracellular parasite often found in the brain of humans. Research has shown a correlation between prevalence of antibody titers to T. gondii and psychological illness in humans. Recent ...
    • High-frequency irreversible electroporation (H-FIRE) for non-thermal ablation without muscle contraction 

      Arena, Christopher B.; Sano, Michael B.; Rossmeisl, John H.; Caldwell, John L.; Garcia, Paulo A.; Rylander, Marissa N.; Davalos, Rafael V. (2011-11-21)
      Background Therapeutic irreversible electroporation (IRE) is an emerging technology for the non-thermal ablation of tumors. The technique involves delivering a series of unipolar electric pulses to permanently destabilize ...