Now showing items 1-7 of 7

    • Agrin and Synaptic Laminin Are Required to Maintain Adult Neuromuscular Junctions 

      Samuel, Melanie; Valdez, Gregorio; Tapia, Juan C.; Lichtman, Jeff W.; Sanes, Joshua R. (PLOS, 2012-10-03)
      As synapses form and mature the synaptic partners produce organizing molecules that regulate each other’s differentiation and ensure precise apposition of pre- and post-synaptic specializations. At the skeletal neuromuscular ...
    • The ALS-inducing factors, TDP43A315T and SOD1G93A, directly affect and sensitize sensory neurons to stress 

      Vaughan, Sydney K.; Sutherland, Natalia M.; Zhang, Sihui; Hatzipetros, Theo; Vieira, Fernando; Valdez, Gregorio (Nature, 2018-11-08)
      There is increased recognition that sensory neurons located in dorsal root ganglia (DRG) are affected in amyotrophic lateral sclerosis (ALS). However, it remains unknown whether ALS-inducing factors, other than mutant ...
    • Laminins promote postsynaptic maturation by an autocrine mechanism at the neuromuscular junction 

      Nishimune, Hiroshi; Valdez, Gregorio; Jarad, George; Moulson, Casey L.; Müller, Ulrich; Miner, Jeffrey H.; Sanes, Joshua R. (The Rockefeller University Press, 2008-09-15)
      A prominent feature of synaptic maturation at the neuromuscular junction (NMJ) is the topological transformation of the acetylcholine receptor (AChR)-rich postsynaptic membrane from an ovoid plaque into a complex array of ...
    • 𝛼-Motor neurons are spared from aging while their synaptic inputs degenerate in monkeys and mice 

      Maxwell, Nicholas; Castro, Ryan W.; Sutherland, Natalia M.; Vaughan, Kelli L.; Szarowicz, Mark D.; de Cabo, Rafael; Mattison, Julie A.; Valdez, Gregorio (Wiley, 2017)
      Motor function deteriorates with advancing age, increasing the risk of adverse health outcomes. While it is well established that skeletal muscles and neuromuscular junctions (NMJs) degenerate with increasing age, the ...
    • The Role of Muscle microRNAs in Repairing the Neuromuscular Junction 

      Valdez, Gregorio; Heyer, Mary P.; Feng, Guoping; Sanes, Joshua R. (PLOS, 2014-03-24)
      microRNAs have been implicated in mediating key aspects of skeletal muscle development and responses to diseases and injury. Recently, we demonstrated that a synaptically enriched microRNA, miR-206, functions to promote ...
    • Shared Resistance to Aging and ALS in Neuromuscular Junctions of Specific Muscles 

      Valdez, Gregorio; Tapia, Juan C.; Lichtman, Jeff W.; Fox, Michael A.; Sanes, Joshua R. (PLOS, 2012-04-02)
      Normal aging and neurodegenerative diseases both lead to structural and functional alterations in synapses. Comparison of synapses that are generally similar but respond differently to insults could provide the basis for ...
    • Specific labeling of synaptic schwann cells reveals unique cellular and molecular features 

      Castro, Ryan; Taetzsch, Thomas; Vaughan, Sydney K.; Godbe, Kerilyn; Chappell, John; Settlage, Robert E.; Valdez, Gregorio (2020-06-25)
      Perisynaptic Schwann cells (PSCs) are specialized, non-myelinating, synaptic glia of the neuromuscular junction (NMJ), that participate in synapse development, function, maintenance, and repair. The study of PSCs has relied ...