Now showing items 1-6 of 6
Nuclei-specific differences in nerve terminal distribution, morphology, and development in mouse visual thalamus
Background: Mouse visual thalamus has emerged as a powerful model for understanding the mechanisms underlying neural circuit formation and function. Three distinct nuclei within mouse thalamus receive retinal input, the ...
A Molecular Mechanism Regulating the Timing of Corticogeniculate Innervation
Neural circuit formation demands precise timing of innervation by different classes of axons. However, the mechanisms underlying such activity remain largely unknown. In the dorsal lateral geniculate nucleus (dLGN), axons ...
F-spondin Is Essential for Maintaining Circadian Rhythms
The suprachiasmatic nucleus (SCN) is the master pacemaker that drives circadian behaviors. SCN neurons have intrinsic, self-sustained rhythmicity that is governed by transcription-translation feedback loops. Intrinsic ...
Fibroblast growth factor 22 contributes to the development of retinal nerve terminals in the dorsal lateral geniculate nucleus
At least three forms of signaling between pre- and postsynaptic partners are necessary during synapse formation. First, “targeting” signals instruct presynaptic axons to recognize and adhere to the correct portion of a ...
Collagen-derived matricryptins promote inhibitory nerve terminal formation in the developing neocortex
(Rockefeller University Press, 2016-03-14)
Inhibitory synapses comprise only ∼20% of the total synapses in the mammalian brain but play essential roles in controlling neuronal activity. In fact, perturbing inhibitory synapses is associated with complex brain ...
Toxoplasma gondii Infections Alter GABAergic Synapses and Signaling in the Central Nervous System
(American Society for Microbiology, 2015-10-27)
During infections with the protozoan parasite Toxoplasma gondii, gamma-aminobutyric acid (GABA) is utilized as a carbon source for parasite metabolism and also to facilitate parasite dissemination by stimulating dendritic-cell ...