Now showing items 1-10 of 138
The Role of Perspective-Taking on Ability to Recognize Fear
Impairment in the ability to detect certain emotions, such as fear, is linked to multiple disorders and follows a pattern of interindividual variability and intra-individual stability over time. Deficits in fear recognition ...
Motor Deficits and Decreased Striatal Dopamine Receptor 2 Binding Activity in the Striatum-Specific Dyt1 Conditional Knockout Mice
DYT1 early-onset generalized dystonia is a hyperkinetic movement disorder caused by mutations in DYT1 (TOR1A), which codes for torsinA. Recently, significant progress has been made in studying pathophysiology of DYT1 ...
The evolution of self-control
Cognition presents evolutionary research with one of its greatest challenges. Cognitive evolution has been explained at the proximate level by shifts in absolute and relative brain volume and at the ultimate level by ...
Mathematical Modeling for the Pathogenesis of Alzheimer's Disease
Despite extensive research, the pathogenesis of neurodegenerative Alzheimer's disease (AD) still eludes our comprehension. This is largely due to complex and dynamic cross-talks that occur among multiple cell types throughout ...
Perineuronal nets decrease membrane capacitance of peritumoral fast spiking interneurons in a model of epilepsy
(Springer Nature, 2018-11-09)
Brain tumor patients commonly present with epileptic seizures. We show that tumor-associated seizures are the consequence of impaired GABAergic inhibition due to an overall loss of peritumoral fast spiking interneurons ...
RNA sequencing and proteomics approaches reveal novel deficits in the cortex ofMecp2-deficient mice, a model for Rett syndrome.
BACKGROUND: Rett syndrome (RTT) is an X-linked neurodevelopmental disorder caused by mutations in the transcriptional regulator MeCP2. Much of our understanding of MeCP2 function is derived from transcriptomic studies with ...
Molecular mechanisms of experience-dependent plasticity in visual cortex
(Royal Society, 2008)
A remarkable amount of our current knowledge of mechanisms underlying experience-dependent plasticity during cortical development comes from study of the mammalian visual cortex. Recent advances in high-resolution cellular ...
The Role of Class IA Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunits in Glioblastoma
(Frontiers Media Sa, 2017-12-15)
Inhibitory Control Mediates the Association between Perceived Stress and Secure Relationship Quality
Past research has demonstrated negative associations between exposure to stressors and quality of interpersonal relationships among children and adolescents. Nevertheless, underlying mechanisms of this association remain ...
Central Presynaptic Terminals Are Enriched in ATP but the Majority Lack Mitochondria
Synaptic neurotransmission is known to be an energy demanding process. At the presynapse, ATP is required for loading neurotransmitters into synaptic vesicles, for priming synaptic vesicles before release, and as a substrate ...