Now showing items 21-30 of 96
LRRTM1 underlies synaptic convergence in visual thalamus
It has long been thought that the mammalian visual system is organized into parallel pathways, with incoming visual signals being parsed in the retina based on feature (e.g. color, contrast and motion) and then transmitted ...
Posttraumatic Stress Among Students After the Shootings at Virginia Tech
(Psychological Trauma: Theory, Research, Practice, and Policy, 2011-07-18)
On April 16, 2007, in the worst campus shooting incident in U.S. history, 49 students and faculty at Virginia Polytechnic Institute and State University (Virginia Tech) were shot, of whom 32 were killed. A cross-sectional ...
Estrogen receptor α drives pro-resilient transcription in mouse models of depression
(Nature Publishing Group, 2018-03-16)
Most people exposed to stress do not develop depression. Animal models have shown that stress resilience is an active state that requires broad transcriptional adaptations, but how this homeostatic process is regulated ...
Tumor-Specific Chromosome Mis-Segregation Controls Cancer Plasticity by Maintaining Tumor Heterogeneity
Aneuploidy with chromosome instability is a cancer hallmark. We studied chromosome 7 (Chr7) copy number variation (CNV) in gliomas and in primary cultures derived from them. We found tumor heterogeneity with cells having ...
Enduring deficits in memory and neuronal pathology after blast-induced traumatic brain injury
(Nature Publishing Group, 2015-11-05)
The Role of Muscle microRNAs in Repairing the Neuromuscular Junction
microRNAs have been implicated in mediating key aspects of skeletal muscle development and responses to diseases and injury. Recently, we demonstrated that a synaptically enriched microRNA, miR-206, functions to promote ...
GABA(B) receptor-dependent bidirectional regulation of critical period ocular dominance plasticity in cats
Gama amino butyric acid (GABA) inhibition plays an important role in the onset and offset of the critical period for ocular dominance (OD) plasticity in the primary visual cortex. Previous studies have focused on the ...
Effects of a behavioral and health literacy intervention to reduce sugar-sweetened beverages: a randomized-controlled trial
(Biomed Central Ltd, 2016-03-22)
Effectiveness of a Worksite-Based Weight Loss Randomized Controlled Trial: The Worksite Study
Distinguishing the Unique Neuropathological Profile of Blast Polytrauma
Traumatic brain injury sustained after blast exposure (blast-induced TBI) has recently been documented as a growing issue for military personnel. Incidence of injury to organs such as the lungs has decreased, though current ...