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dc.contributorVirginia Tech
dc.contributor.authorHelekar, Santosh A.
dc.contributor.authorShin, Jae C.
dc.contributor.authorMattson, Brandi J.
dc.contributor.authorBartley, Krystle
dc.contributor.authorStosic, Milena
dc.contributor.authorSaldana-King, Toni
dc.contributor.authorMontague, P. Read
dc.contributor.authorHutton, George J.
dc.date.accessioned2017-09-26T13:07:51Z
dc.date.available2017-09-26T13:07:51Z
dc.date.issued2010-11-22
dc.identifier.urihttp://hdl.handle.net/10919/79415
dc.description.abstractIn multiple sclerosis (MS) functional changes in connectivity due to cortical reorganization could lead to cognitive impairment (CI), or reflect a re-adjustment to reduce the clinical effects of widespread tissue damage. Such alterations in connectivity could result in changes in neural activation as assayed by executive function tasks. We examined cognitive function in MS patients with mild to moderate CI and age-matched controls. We evaluated brain activity using functional magnetic resonance imaging (fMRI) during the successful performance of the Wisconsin card sorting (WCS) task by MS patients, showing compensatory maintenance of normal function, as measured by response latency and error rate. To assess changes in functional connectivity throughout the brain, we performed a global functional brain network analysis by computing voxel-by-voxel correlations on the fMRI time series data and carrying out a hierarchical cluster analysis. We found that during the WCS task there is a significant reduction in the number of smaller size brain functional networks, and a change in the brain areas representing the nodes of these networks in MS patients compared to age-matched controls. There is also a concomitant increase in the strength of functional connections between brain loci separated at intermediate-scale distances in these patients. These functional alterations might reflect compensatory neuroplastic reorganization underlying maintenance of relatively normal cognitive function in the face of white matter lesions and cortical atrophy produced by MS.
dc.language.isoen_US
dc.publisherFrontiers
dc.subjectconnectivity
dc.subjectdemyelination
dc.subjectwhite matter
dc.subjectplasticity
dc.subjectneuroimaging
dc.subjectfMRI
dc.titleFunctional brain network changes associated with maintenance of cognitive function in multiple sclerosis
dc.typeArticle - Refereed
dc.title.serialFrontiers in Human Neuroscience
dc.identifier.doihttps://doi.org/10.3389/fnhum.2010.00219
dc.identifier.volume4


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