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dc.contributorVirginia Techen
dc.contributor.authorHelekar, Santosh A.en
dc.contributor.authorShin, Jae C.en
dc.contributor.authorMattson, Brandi J.en
dc.contributor.authorBartley, Krystleen
dc.contributor.authorStosic, Milenaen
dc.contributor.authorSaldana-King, Tonien
dc.contributor.authorMontague, P. Readen
dc.contributor.authorHutton, George J.en
dc.date.accessioned2017-09-26T13:07:51Zen
dc.date.available2017-09-26T13:07:51Zen
dc.date.issued2010-11-22en
dc.identifier.urihttp://hdl.handle.net/10919/79415en
dc.description.abstractIn multiple sclerosis (MS) functional changes in connectivity due to cortical reorganization could lead to cognitive impairment (CI), or reflect a re-adjustment to reduce the clinical effects of widespread tissue damage. Such alterations in connectivity could result in changes in neural activation as assayed by executive function tasks. We examined cognitive function in MS patients with mild to moderate CI and age-matched controls. We evaluated brain activity using functional magnetic resonance imaging (fMRI) during the successful performance of the Wisconsin card sorting (WCS) task by MS patients, showing compensatory maintenance of normal function, as measured by response latency and error rate. To assess changes in functional connectivity throughout the brain, we performed a global functional brain network analysis by computing voxel-by-voxel correlations on the fMRI time series data and carrying out a hierarchical cluster analysis. We found that during the WCS task there is a significant reduction in the number of smaller size brain functional networks, and a change in the brain areas representing the nodes of these networks in MS patients compared to age-matched controls. There is also a concomitant increase in the strength of functional connections between brain loci separated at intermediate-scale distances in these patients. These functional alterations might reflect compensatory neuroplastic reorganization underlying maintenance of relatively normal cognitive function in the face of white matter lesions and cortical atrophy produced by MS.en
dc.language.isoen_USen
dc.publisherFrontiersen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectconnectivityen
dc.subjectdemyelinationen
dc.subjectwhite matteren
dc.subjectplasticityen
dc.subjectneuroimagingen
dc.subjectfMRIen
dc.titleFunctional brain network changes associated with maintenance of cognitive function in multiple sclerosisen
dc.typeArticle - Refereeden
dc.title.serialFrontiers in Human Neuroscienceen
dc.identifier.doihttps://doi.org/10.3389/fnhum.2010.00219en
dc.identifier.volume4en


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