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dc.contributorVirginia Tech
dc.contributor.authorBerns, Gregory S.
dc.contributor.authorMcClure, Samuel M.
dc.contributor.authorPagnoni, Guiseppe
dc.contributor.authorMontague, P. Read
dc.date.accessioned2017-09-26T13:07:52Z
dc.date.available2017-09-26T13:07:52Z
dc.date.issued2001-04-15
dc.identifier.urihttp://hdl.handle.net/10919/79422
dc.description.abstractCertain classes of stimuli, such as food and drugs, are highly effective in activating reward regions. We show in humans that activity in these regions can be modulated by the predictability of the sequenced delivery of two mildly pleasurable stimuli, orally delivered fruit juice and water. Using functional magnetic resonance imaging, the activity for rewarding stimuli in both the nucleus accumbens and medial orbitofrontal cortex was greatest when the stimuli were unpredictable. Moreover, the subjects’ stated preference for either juice or water was not directly correlated with activity in reward regions but instead was correlated with activity in sensorimotor cortex. For pleasurable stimuli, these findings suggest that predictability modulates the response of human reward regions, and subjective preference can be dissociated from this response.
dc.language.isoen_US
dc.publisherSociety for Neuroscience
dc.subjectreward
dc.subjectdopamine
dc.subjectfMRI
dc.subjectreinforcement
dc.subjectneural network
dc.subjectnucleus accumbens
dc.subjectstriatum
dc.titlePredictability Modulates Human Brain Response to Reward
dc.typeArticle
dc.title.serialThe Journal of Neuroscience
dc.identifier.volume21
dc.identifier.issue8


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