Now showing items 1-18 of 18

    • A Model for a Smallpox-Vaccination Policy 

      Bozzette, Samuel A.; Boer, Rob; Bhatnagar, Vibha; Brower, Jennifer L.; Keeler, Emmett B.; Morton, Sally C.; Stoto, Michael A. (NEJM Group, 2003-01-30)
      Background: The new reality of biologic terrorism and warfare has ignited a debate about whether to reintroduce smallpox vaccination. Methods: We developed scenarios of smallpox attacks and built a stochastic model of ...
    • Are Ayurvedic herbs for diabetes effective? 

      Shekelle, Paul G.; Hardy, Mary; Morton, Sally C.; Coulter, Ian; Venuturupalli, Swamy; Favreau, Joya; Hilton, Lara K. (Frontline Medical Communications Inc., 2005-10)
      Objective: To evaluate and synthesize the evidence on the effect of Ayurvedic therapies for diabetes mellitus. Design: Systematic review of trials. Measurements and main results: We found no study that assessed ...
    • Comparing Effectiveness of Top-Down and Bottom-Up Strategies in Containing Influenza 

      Marathe, Achla; Lewis, Bryan L.; Barrett, Christopher L.; Chen, Jiangzhuo; Marathe, Madhav; Eubank, Stephen; Ma, Yifei (Public Library of Science, 2011-09-22)
      This research compares the performance of bottom-up, self-motivated behavioral interventions with top-down interventions targeted at controlling an “Influenza-like-illness”. Both types of interventions use a variant of the ...
    • Control of mitochondrial metabolism and systemic energy homeostasis by microRNAs 378 and 378* 

      Carrer, Michele; Liu, Ning; Grueter, Chad E.; Williams, Andrew H.; Frisard, Madlyn I.; Hulver, Matthew W.; Bassel-Duby, Rhonda; Olson, Eric N. (NAS, 2012-09-18)
      Obesity and metabolic syndrome are associated with mitochondrial dysfunction and deranged regulation of metabolic genes. Peroxisome proliferator-activated receptor γ coactivator 1β (PGC-1β) is a transcriptional coactivator ...
    • Describing the Relationship between Cat Bites and Human Depression Using Data from an Electronic Health Record 

      Hanauer, David A.; Ramakrishnan, Naren; Seyfried, Lisa S. (PLOS, 2013-08-01)
      Data mining approaches have been increasingly applied to the electronic health record and have led to the discovery of numerous clinical associations. Recent data mining studies have suggested a potential association between ...
    • Effects of Omega-3 Fatty Acids on Cancer Risk 

      MacLean, Catherine H.; Newberry, Sydne J.; Mojica, Walter A.; Khanna, Puja; Issa, Amalia M.; Suttorp, Marika J.; Lim, Yee-Wee; Traina, Shana B.; Hilton, Lara; Garland, Rena; Morton, Sally C. (AMA, 2006-04)
      Context: Omega-3 fatty acids are purported to reduce the risk of cancer. Studies have reported mixed results. Objective: To synthesize published and unpublished evidence to determine estimates of the effect of omega-3 ...
    • Efficacy and Safety of Ephedra and Ephedrine for Weight Loss and Athletic Performance: A Meta-analysis 

      Shekelle, Paul G.; Hardy, Mary; Morton, Sally C.; Maglione, Margaret; Mojica, Walter A.; Suttorp, Marika J.; Rhodes, Shannon L.; Jungvig, Lara; Gagné, James (AMA, 2003-03-26)
      CONTEXT: Ephedra and ephedrine sometimes are used for weight loss or enhanced athletic performance, but the efficacy and safety of these compounds are uncertain. OBJECTIVE: To assess the efficacy and safety of ephedra ...
    • Ephedra 

      Morton, Sally C. (Institute of Mathematical Statistics, 2005-08)
      In February 2004, the U.S. Food and Drug Administration (FDA) prohibited the sale of dietary supplements containing ephedrine alkaloids (ephedra), stating that such supplements present an unreasonable risk of illness or ...
    • Fish oil and indomethacin in combination potently reduce dyslipidemia and hepatic steatosis in LDLR⁻/⁻ mice 

      Murali, Ganesan; Milne, Ginger L.; Webb, Corey D.; Stewart, Ann B.; McMillan, Ryan P.; Lyle, Brandon C.; Hulver, Matthew W.; Saraswathi, Viswanathan (ASBMB, 2012-07-29)
      Fish oil (FO) is a potent anti-inflammatory and lipid-lowering agent. Because inflammation can modulate lipid metabolism and vice versa, we hypothesized that combining FO with cyclooxygenase inhibitors (COXIBs), well-known ...
    • Global estimates of CO sources with high resolution by adjoint inversion of multiple satellite datasets (MOPITT, AIRS, SCIAMACHY, TES) 

      Kopacz, M.; Jacob, D. J.; Fisher, J. A.; Logan, J. A.; Zhang, L.; Megretskaia, I. A.; Yantosca, R. M.; Singh, K.; Henze, D. K.; Burrows, J. P.; Buchwitz, M.; Khlystova, I.; McMillan, W. W.; Gille, J. C.; Edwards, D. P.; Eldering, A.; Thouret, V.; Nedelec, P. (Copernicus Publications, 2010)
      We combine CO column measurements from the MOPITT, AIRS, SCIAMACHY, and TES satellite instruments in a full-year (May 2004-April 2005) global inversion of CO sources at 4 degrees x 5 degrees spatial resolution and monthly ...
    • Health beliefs as a key determinant of intent to use anabolic-androgenic steroids (AAS) among high-school football players: implications for prevention 

      Halliburton, Amanda E.; Fritz, Matthew S. (Taylor & Francis, 2017-07-05)
      The use of anabolic-androgenic steroids (AAS) is problematic for youth because of negative effects such as reduced fertility, increased aggression and exposure to toxic chemicals. An effective programme for addressing this ...
    • Human Initiated Cascading Failures in Societal Infrastructures 

      Barrett, Christopher L.; Channakeshava, Karthik; Huang, Fei; Marathe, Achla; Marathe, Madhav V.; Pei, Guanhong; Saha, Sudip; Vullikanti, Anil Kumar S.; Kim, Junwhan; Subbiah, Balaaji S. P. (Public Library of Science, 2012-10-31)
      In this paper, we conduct a systematic study of human-initiated cascading failures in three critical inter-dependent societal infrastructures due to behavioral adaptations in response to a crisis. We focus on three closely ...
    • Interventions for the prevention of falls in older adults: systematic review and meta-analysis of randomised clinical trials 

      Chang, John T.; Morton, Sally C.; Rubenstein, Laurence Z.; Mojica,Walter A.; Maglione, Margaret; Suttorp, Marika J.; Roth, Elizabeth A.; Shekelle, Paul G. (BMJ Publishing Group Ltd, 2004-03-20)
      Objective: To assess the relative effectiveness of interventions to prevent falls in older adults to either a usual care group or control group. Design: Systematic review and meta-analyses. Data sources Medline, ...
    • Quantifying Interhospital Patient Sharing as a Mechanism for Infectious Disease Spread 

      Huang, Susan S.; Avery, Takuser R.; Song, Yeohan H.; Elkins, Kristen R.; Nguyen, Christopher C.; Nutter, Sandra K.; Nafday, Alaka. A.; Condon, Curtis J.; Chang, Michael T.; Chrest, David; Boos, John; Bobashev, Georgiy; Wheaton, William; Frank, Steven A.; Platt, Richard; Lipsitch, Marc; Bush, Robin M.; Eubank, Stephen; Burke, Donald S.; Lee, Bruce Y. (University of Chicago Press, 2010-11)
      BACKGROUND. Assessments of infectious disease spread in hospitals seldom account for interfacility patient sharing. This is particularly important for pathogens with prolonged incubation periods or carrier states. METHODS. ...
    • Text and Data Mining Forum 

      Arrow, Tom; Ewing, E. Thomas; Fan, Weiguo; Fox, Edward A.; House, Leanna L.; Huang, Bert; Pannabecker, Virginia
      This panel discussion was part of Open Data Week 2017 at Virginia Tech. Panelists discussed opportunities and challenges related to text and data mining, with a focus on research purposes and information access. Panelists: ...
    • The effectiveness of computerized order entry at reducing preventable adverse drug events and medication errors in hospital settings: a systematic review and meta-analysis reducing preventable adverse drug events and medication errors in hospital settings: a systematic review and meta-analysis 

      Nuckols, Teryl K.; Smith-Spangler, Crystal; Morton, Sally C.; Asch, Steven M.; Patel, Vaspaan M.; Anderson, Laura J.; Deichsel, Emily L.; Shekelle, Paul G. (BMC, 2014)
      Background: The Health Information Technology for Economic and Clinical Health (HITECH) Act subsidizes implementation by hospitals of electronic health records with computerized provider order entry (CPOE), which may reduce ...
    • The molecular mechanism linking muscle fat accumulation to insulin resistance 

      Dohm, G. Lynis; Hulver, Matthew W. (The Nutrition Society, 2004)
      Skeletal muscle insulin resistance is a co-morbidity of obesity and a risk factor for the development of type 2 diabetes mellitus. Insulin resistance is associated with the accumulation of intramyocellular lipids. ...
    • Therapeutic effects of adropin on glucose tolerance and substrate utilization in diet-induced obese mice with insulin resistance 

      Gao, Su; McMillan, Ryan P.; Zhu, Qingzhang; Lopaschuk, Gary D.; Hulver, Matthew W.; Butler, Andrew A. (Elsevier, 2015-01-17)
      Objective: The peptide hormone adropin regulates fuel selection preferences in skeletal muscle under fed and fasted conditions. Here, we investigated whether adropin treatment can ameliorate the dysregulation of fuel ...