Virginia Tech
    • Log in
    View Item 
    •   VTechWorks Home
    • Destination Areas (DAs) and Strategic Growth Areas (SGAs)
    • Destination Areas (DAs)
    • Destination Area: Data and Decisions (D&D)
    • View Item
    •   VTechWorks Home
    • Destination Areas (DAs) and Strategic Growth Areas (SGAs)
    • Destination Areas (DAs)
    • Destination Area: Data and Decisions (D&D)
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Fish oil and indomethacin in combination potently reduce dyslipidemia and hepatic steatosis in LDLR⁻/⁻ mice

    Thumbnail
    View/Open
    HulverFishOil2012.pdf (1.761Mb)
    Downloads: 126
    Date
    2012-07-29
    Author
    Murali, Ganesan
    Milne, Ginger L.
    Webb, Corey D.
    Stewart, Ann B.
    McMillan, Ryan P.
    Lyle, Brandon C.
    Hulver, Matthew W.
    Saraswathi, Viswanathan
    Metadata
    Show full item record
    Abstract
    Fish oil (FO) is a potent anti-inflammatory and lipid-lowering agent. Because inflammation can modulate lipid metabolism and vice versa, we hypothesized that combining FO with cyclooxygenase inhibitors (COXIBs), well-known anti-infl ammatory drugs, can enhance the antiinfl ammatory and lipid-lowering effect of FO. LDLR⁻/⁻ mice were fed a high-fat diet supplemented with 6% olive oil or FO for 12 wk in the presence or absence of indomethacin (Indo, 6 mg/l drinking water). FO reduced plasma total cholesterol by 30% but, in combination with Indo, exerted a greater decrease (44%). The reduction of liver cholesterol ester (CE) and triglycerides (TG) by FO (63% and 41%, respectively) was enhanced by Indo (80% in CE and 64% in TG). FO + Indo greatly increased the expression of genes modulating lipid metabolism and reduced the expression of inflammatory genes compared with control. The mRNA and/or protein expression of pregnane X receptor (PXR) and cytochrome P450 isoforms that alter inflammation and/or lipid metabolism are increased to a greater extent in mice that received FO + Indo. Moreover, the nuclear level of PXR is significantly increased in FO + Indo group. Combining FO with COXIBs may exert their beneficial effects on inflammation and lipid metabolism via PXR and cytochrome P450.
    URI
    http://hdl.handle.net/10919/79623
    Collections
    • Destination Area: Data and Decisions (D&D) [126]
    • Scholarly Works, Department of Human Nutrition, Foods, and Exercise [239]

    If you believe that any material in VTechWorks should be removed, please see our policy and procedure for Requesting that Material be Amended or Removed. All takedown requests will be promptly acknowledged and investigated.

    Virginia Tech | University Libraries | Contact Us
     

     

    VTechWorks

    AboutPoliciesHelp

    Browse

    All of VTechWorksCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    Log inRegister

    Statistics

    View Usage Statistics

    If you believe that any material in VTechWorks should be removed, please see our policy and procedure for Requesting that Material be Amended or Removed. All takedown requests will be promptly acknowledged and investigated.

    Virginia Tech | University Libraries | Contact Us