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dc.contributorVirginia Techen
dc.contributor.authorDorratoltaj, Nargesalsadaten
dc.contributor.authorMarathe, Achlaen
dc.contributor.authorLewis, Bryan L.en
dc.contributor.authorSwarup, Samarthen
dc.contributor.authorEubank, Stephen G.en
dc.contributor.authorAbbas, Kaja M.en
dc.date.accessioned2017-10-27T17:45:21Zen
dc.date.available2017-10-27T17:45:21Zen
dc.date.issued2017-06-01en
dc.identifier.urihttp://hdl.handle.net/10919/79824en
dc.description.abstractThe study objective is to estimate the epidemiological and economic impact of vaccine interventions during influenza pandemics in Chicago, and assist in vaccine intervention priorities. Scenarios of delay in vaccine introduction with limited vaccine efficacy and limited supplies are not unlikely in future influenza pandemics, as in the 2009 H1N1 influenza pandemic. We simulated influenza pandemics in Chicago using agent-based transmission dynamic modeling. Population was distributed among high-risk and non-high risk among 0±19, 20±64 and 65+ years subpopulations. Different attack rate scenarios for catastrophic (30.15%), strong (21.96%), and moderate (11.73%) influenza pandemics were compared against vaccine intervention scenarios, at 40% coverage, 40% efficacy, and unit cost of $28.62. Sensitivity analysis for vaccine compliance, vaccine efficacy and vaccine start date was also conducted. Vaccine prioritization criteria include risk of death, total deaths, net benefits, and return on investment. The risk of death is the highest among the high-risk 65+ years subpopulation in the catastrophic influenza pandemic, and highest among the high-risk 0±19 years subpopulation in the strong and moderate influenza pandemics. The proportion of total deaths and net benefits are the highest among the high-risk 20±64 years subpopulation in the catastrophic, strong and moderate influenza pandemics. The return on investment is the highest in the high-risk 0±19 years subpopulation in the catastrophic, strong and moderate influenza pandemics. Based on risk of death and return on investment, high-risk groups of the three age group subpopulations can be prioritized for vaccination, and the vaccine interventions are cost saving for all age and risk groups. The attack rates among the children are higher than among the adults and seniors in the catastrophic, strong, and moderate influenza pandemic scenarios, due to their larger social contact network and homophilous interactions in school. Based on return on investment and higher attack rates among children, we recommend prioritizing children (0±19 years) and seniors (65+ years) after high-risk groups for influenza vaccination during times of limited vaccine supplies. Based on risk of death, we recommend prioritizing seniors (65+ years) after high-risk groups for influenza vaccination during times of limited vaccine supplies.en
dc.description.sponsorshipThis study is supported by NIH NIGMS R01GM109718, NSF-ICES 1216000, NSF NRT- DESE 1545362, DTRA HDTRA1-11-1-0016, and DTRA HDTRA1-11-D-0016-0001.en
dc.language.isoen_USen
dc.publisherPLOSen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.titleEpidemiological and economic impact of pandemic influenza in Chicago: Priorities for vaccine interventionsen
dc.typeArticle - Refereeden
dc.title.serialPLOS Computational Biologyen
dc.identifier.doihttps://doi.org/10.1371/journal.pcbi.1005521en
dc.identifier.volume13en
dc.identifier.issue6en


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