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dc.contributor.authorPresley, Christopher Charlesen_US
dc.date.accessioned2017-11-07T09:00:18Z
dc.date.available2017-11-07T09:00:18Z
dc.date.issued2017-11-06en_US
dc.identifier.othervt_gsexam:12994en_US
dc.identifier.urihttp://hdl.handle.net/10919/79978
dc.description.abstractAs a part of the continuing search for bioactive compounds with the Madagascar International Cooperative Biodiversity Group (ICBG), and in collaboration with the Natural Products Discovery Institute of the Institute for Hepatitis and Virus Research (IHVR), thirteen plant extracts were investigated for antiplasmodial activity, thirteen plant extracts were investigated for antiproliferative activity, and one extract was investigated for inhibitors of the shikimate pathway in Plasmodium falciparum. Bioassay-guided fractionation of the extracts led to the identification of nineteen compounds with both antiplasmodial and antiproliferative activity, and thirteen compounds with only antiproliferative activity. Thirteen of these compounds (2.1 – 2.9, 3.3, 3.4, 4.5, and 5.1) were previously unknown. In addition total synthesis was used to confirm the structure of one new compound (4.5) and two other new natural-product like compounds (4.6 and 4.7) were also synthesized and investigated for antiplasmodial activity.en_US
dc.format.mediumETDen_US
dc.publisherVirginia Techen_US
dc.rightsThis item is protected by copyright and/or related rights. Some uses of this item may be deemed fair and permitted by law even without permission from the rights holder(s), or the rights holder(s) may have licensed the work for use under certain conditions. For other uses you need to obtain permission from the rights holder(s).en_US
dc.subjectNatural Productsen_US
dc.subjectAntiproliferativeen_US
dc.subjectAntiplasmodialen_US
dc.subjectChromaneen_US
dc.subjectChromeneen_US
dc.subjectCrinumen_US
dc.subjectCripowellinen_US
dc.subjectQuinoloneen_US
dc.subjectDiterpeneen_US
dc.subjectTriterpeneen_US
dc.titleIsolation, Structure Elucidation, and Total Synthesis of Biologically Active Natural Products from Plantsen_US
dc.typeDissertationen_US
dc.contributor.departmentChemistryen_US
dc.description.degreePh. D.en_US
thesis.degree.namePh. D.en_US
thesis.degree.leveldoctoralen_US
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen_US
thesis.degree.disciplineChemistryen_US
dc.contributor.committeechairKingston, David G. I.en_US
dc.contributor.committeememberSantos, Websteren_US
dc.contributor.committeememberCarlier, Paul R.en_US
dc.contributor.committeememberJosan, Jatinderen_US


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