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dc.contributor.authorEdd, Jon F.
dc.contributor.authorDavalos, Rafael V.
dc.date.accessioned2017-11-08T16:21:01Z
dc.date.available2017-11-08T16:21:01Z
dc.date.issued2007-08
dc.identifier.urihttp://hdl.handle.net/10919/80000
dc.description.abstractIrreversible Electroporation (IRE) is a new drug-free method to ablate undesirable tissue of particular use in cancer therapy. IRE achieves cell death within the targeted tissue through a series of electric pulses that elevate the transmembrane potentials to an extent that permanently damages the lipid bilayers throughout the treated region. Although the IRE procedure is easy to perform, treatment planning is complicated by the fact that the electric field distribution within the tissue, the greatest single factor controlling the extents of IRE, depends non-trivially on the electrode configuration, pulse parameters and any tissue heterogeneities. To address this difficulty, we instruct on how to properly model IRE and discuss the benefit of modeling in designing treatment protocols. The necessary theoretical basis is introduced and discussed through the detailed analysis of two classic dual-electrode configurations from electrochemotherapy: coaxial disk electrodes and parallel needle electrodes. Dimensionless figures for these cases are also provided that allow cell constants, treated areas, and the details of heating to be determined for a wide range of conditions, for uniform tissues, simply by plugging in the appropriate physical property values and pulse parameters such as electrode spacing, size, and pulse amplitude. Complexities, such as heterogeneous tissues and changes in conductivity due to electroporation, are also discussed. The synthesis of these details can be used directly by surgeons in treatment planning. Irreversible electroporation is a promising new technique to treat cancer in a targeted manner without the use of drugs; however, it does require a detailed understanding of how electric currents flow within biological tissues. By providing the understanding and tools necessary to design an IRE protocol, this study seeks to facilitate the translation of this new and exciting cancer therapy into clinical practice.en_US
dc.language.isoen_USen_US
dc.publisherSageen_US
dc.subjectTumor ablationen_US
dc.subjectComplete regressionen_US
dc.subjectElectric pulsesen_US
dc.subjectElectropermeabilizationen_US
dc.subjectPulsed electric fields (PEFs)en_US
dc.subjectCancer therapyen_US
dc.titleMathematical Modeling of Irreversible Electroporation for Treatment Planningen_US
dc.typeArticleen_US
dc.title.serialTechnology in Cancer Research and Treatmenten_US
dc.identifier.doihttps://doi.org/10.1177/153303460700600403
dc.identifier.volume6en_US
dc.identifier.issue4en_US


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