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dc.contributor.authorWei, Yunen_US
dc.contributor.authorCheng, Biaoen_US
dc.contributor.authorZhu, Guodingen_US
dc.contributor.authorShen, Danyuen_US
dc.contributor.authorLiang, Jiangtaoen_US
dc.contributor.authorWang, Congen_US
dc.contributor.authorWang, Jingen_US
dc.contributor.authorTang, Jianxiaen_US
dc.contributor.authorCao, Junen_US
dc.contributor.authorSharakhov, Igor V.en_US
dc.contributor.authorXia, Aien_US
dc.date.accessioned2018-01-02T23:00:55Z
dc.date.available2018-01-02T23:00:55Z
dc.date.issued2017-06-05en_US
dc.identifier.citationMalaria Journal. 2017 Jun 05;16(1):235
dc.identifier.issn1475-2875en_US
dc.identifier.urihttp://hdl.handle.net/10919/81471
dc.description.abstractBackground Anopheles sinensis is a dominant natural vector of Plasmodium vivax in China, Taiwan, Japan, and Korea. Recent genome sequencing of An. sinensis provides important insights into the genomic basis of vectorial capacity. However, the lack of a physical genome map with chromosome assignment and orientation of sequencing scaffolds hinders comparative analyses with other genomes to infer evolutionary changes relevant to the vector capacity. Results Here, a physical genome map for An. sinensis was constructed by assigning 52 scaffolds onto the chromosomes using fluorescence in situ hybridization (FISH). This chromosome-based genome assembly composes approximately 36% of the total An. sinensis genome. Comparisons of 3955 orthologous genes between An. sinensis and Anopheles gambiae identified 361 conserved synteny blocks and 267 inversions fixed between these two lineages. The rate of gene order reshuffling on the X chromosome is approximately 3.2 times higher than that on the autosomes. Conclusions The physical map will facilitate detailed genomic analysis of An. sinensis and contribute to understanding of the patterns and mechanisms of large-scale genome rearrangements in anopheline mosquitoes.
dc.format.extent? - ? (10) page(s)en_US
dc.format.mimetypeapplication/pdf
dc.language.isoen_US
dc.publisherBiomed Central Ltden_US
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000403851200001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en_US
dc.rightsCreative Commons Attribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectInfectious Diseasesen_US
dc.subjectParasitologyen_US
dc.subjectTropical Medicineen_US
dc.subjectChromosomal evolutionen_US
dc.subjectGRIMMen_US
dc.subjectInversion fixationen_US
dc.subjectFluorescence in situ hybridizationen_US
dc.subjectOrthoDBen_US
dc.subjectSynteny blocksen_US
dc.subjectDIPTERA-CULICIDAEen_US
dc.subjectPLASMODIUM-VIVAXen_US
dc.subjectGENUS ANOPHELESen_US
dc.subjectCENTRAL CHINAen_US
dc.subjectMOSQUITOen_US
dc.subjectSEQUENCEen_US
dc.subjectREARRANGEMENTSen_US
dc.subjectCHROMOSOMESen_US
dc.subjectEVOLUTIONen_US
dc.subjectSTEPHENSIen_US
dc.titleComparative physical genome mapping of malaria vectors Anopheles sinensis and Anopheles gambiaeen_US
dc.typeArticle - Refereed
dc.description.versionPublished (Publication status)en_US
dc.rights.holderThe Author(s)
dc.contributor.departmentEntomologyen_US
dc.contributor.departmentFralin Life Sciences Instituteen_US
dc.title.serialMALARIA JOURNALen_US
dc.identifier.doihttps://doi.org/10.1186/s12936-017-1888-7
dc.identifier.volume16en_US
dc.identifier.orcidSharakhov, IV [0000-0003-0752-3747]en_US
dc.type.dcmitypeText
pubs.organisational-group/Virginia Tech
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/CALS T&R Faculty
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/Entomology
pubs.organisational-group/Virginia Tech/All T&R Faculty
pubs.organisational-group/Virginia Tech/Faculty of Health Sciences
pubs.organisational-group/Virginia Tech/University Research Institutes
pubs.organisational-group/Virginia Tech/University Research Institutes/Fralin Life Sciences
pubs.organisational-group/Virginia Tech/University Research Institutes/Fralin Life Sciences/Fralin Affiliated Faculty


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Creative Commons Attribution 4.0 International
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