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dc.contributor.authorVan Wart, Audra
dc.contributor.authorLyckman, Alvin W.
dc.contributor.authorHorng, Sam
dc.contributor.authorLeamey, Catherine A.
dc.contributor.authorTropea, Daniela
dc.contributor.authorWatakabe, Akiya
dc.contributor.authorMcCurry, Cortina
dc.contributor.authorYamamori, Tetsuo
dc.contributor.authorSur, Mriganka
dc.date.accessioned2018-05-25T17:49:41Z
dc.date.available2018-05-25T17:49:41Z
dc.date.issued2008-07
dc.identifier.urihttp://hdl.handle.net/10919/83396
dc.description.abstractThe mapping of eye-specific, geniculocortical inputs to primary visual cortex (V1) is highly sensitive to the balance of correlated activity between the two eyes during a restricted postnatal critical period for ocular dominance plasticity. This critical period is likely to have amplified expression of genes and proteins that mediate synaptic plasticity. DNA microarray analysis of transcription in mouse V1 before, during, and after the critical period identified 31 genes that were up-regulated and 22 that were down-regulated during the critical period. The highest-ranked up-regulated gene, cardiac troponin C, codes for a neuronal calcium-binding protein that regulates actin binding and whose expression is activity-dependent and relatively selective for layer-4 star pyramidal neurons. The highest-ranked down-regulated gene, synCAM, also has actin-based function. Actinbinding function, G protein signaling, transcription, and myelination are prominently represented in the critical period transcriptome. Monocular deprivation during the critical period reverses the expression of nearly all critical period genes. The profile of regulated genes suggests that synaptic stability is a principle driver of critical period gene expression and that alteration in visual activity drives homeostatic restoration of stability.en_US
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.publisherNational Academy of Sciencesen_US
dc.subjectActinen_US
dc.subjectMyelinen_US
dc.subjectOcular dominanceen_US
dc.subjectSynaptic plasticityen_US
dc.subjectTroponinen_US
dc.titleGene expression patterns in visual cortex during the critical period: Synaptic stabilization and reversal by visual deprivationen_US
dc.typeArticle - Refereeden_US
dc.rights.holderCopyright 2008 National Academy of Sciences
dc.description.notespp. 9409-9414

This article contains supporting information online at www.pnas.org/cgi/content/full/ 0710172105/DCSupplemental.

en_US
dc.identifier.urlhttp://www.pnas.org/content/105/27/9409
dc.title.serialProceedings of the National Academy of Sciences of the United States of Americaen_US
dc.identifier.doihttps://doi.org/10.1073/pnas.0710172105
dc.identifier.volume105en_US
dc.identifier.issue27en_US
dc.type.dcmitypeText


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