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dc.contributor.authorVan Wart, Audraen
dc.contributor.authorLyckman, Alvin W.en
dc.contributor.authorHorng, Samen
dc.contributor.authorLeamey, Catherine A.en
dc.contributor.authorTropea, Danielaen
dc.contributor.authorWatakabe, Akiyaen
dc.contributor.authorMcCurry, Cortinaen
dc.contributor.authorYamamori, Tetsuoen
dc.contributor.authorSur, Mrigankaen
dc.date.accessioned2018-05-25T17:49:41Zen
dc.date.available2018-05-25T17:49:41Zen
dc.date.issued2008-07en
dc.identifier.urihttp://hdl.handle.net/10919/83396en
dc.description.abstractThe mapping of eye-specific, geniculocortical inputs to primary visual cortex (V1) is highly sensitive to the balance of correlated activity between the two eyes during a restricted postnatal critical period for ocular dominance plasticity. This critical period is likely to have amplified expression of genes and proteins that mediate synaptic plasticity. DNA microarray analysis of transcription in mouse V1 before, during, and after the critical period identified 31 genes that were up-regulated and 22 that were down-regulated during the critical period. The highest-ranked up-regulated gene, cardiac troponin C, codes for a neuronal calcium-binding protein that regulates actin binding and whose expression is activity-dependent and relatively selective for layer-4 star pyramidal neurons. The highest-ranked down-regulated gene, synCAM, also has actin-based function. Actinbinding function, G protein signaling, transcription, and myelination are prominently represented in the critical period transcriptome. Monocular deprivation during the critical period reverses the expression of nearly all critical period genes. The profile of regulated genes suggests that synaptic stability is a principle driver of critical period gene expression and that alteration in visual activity drives homeostatic restoration of stability.en
dc.format.mimetypeapplication/pdfen
dc.language.isoen_USen
dc.publisherNational Academy of Sciencesen
dc.subjectActinen
dc.subjectMyelinen
dc.subjectOcular dominanceen
dc.subjectSynaptic plasticityen
dc.subjectTroponinen
dc.titleGene expression patterns in visual cortex during the critical period: Synaptic stabilization and reversal by visual deprivationen
dc.typeArticle - Refereeden
dc.rights.holderCopyright 2008 National Academy of Sciencesen
dc.description.notespp. 9409-9414

This article contains supporting information online at www.pnas.org/cgi/content/full/ 0710172105/DCSupplemental.

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dc.identifier.urlhttp://www.pnas.org/content/105/27/9409en
dc.title.serialProceedings of the National Academy of Sciences of the United States of Americaen
dc.identifier.doihttps://doi.org/10.1073/pnas.0710172105en
dc.identifier.volume105en
dc.identifier.issue27en
dc.type.dcmitypeTexten


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