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dc.contributor.authorMunson, Jennifer M.
dc.contributor.authorShieh, Adrian C.
dc.date.accessioned2018-07-27T15:23:49Z
dc.date.available2018-07-27T15:23:49Z
dc.date.issued2014-08-19
dc.identifier.urihttp://hdl.handle.net/10919/84423
dc.description.abstractAs cancer progresses, a dynamic microenvironment develops that creates and responds to cellular and biophysical cues. Increased intratumoral pressure and corresponding increases in interstitial flow from the tumor bulk to the healthy stroma is an observational hallmark of progressing cancers. Until recently, the role of interstitial flow was thought to be mostly passive in the transport and dissemination of cancer cells to metastatic sites. With research spanning the past decade, we have seen that interstitial flow has a promigratory effect on cancer cell invasion in multiple cancer types. This invasion is one mechanism by which cancers can resist therapeutics and recur, but the role of interstitial flow in cancer therapy is limited to the understanding of transport of therapeutics. Here we outline the current understanding of the role of interstitial flow in cancer and the tumor microenvironment through cancer progression and therapy. We also discuss the current role of fluid flow in the treatment of cancer, including drug transport and therapeutic strategies. By stating the current understanding of interstitial flow in cancer progression, we can begin exploring its role in therapeutic failure and treatment resistance.en_US
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.publisherDove Medical Pressen_US
dc.rightsAttribution-NonCommercial 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/*
dc.subjectTumor microenvironmenten_US
dc.subjectInterstitial flowen_US
dc.subjectTherapeuticsen_US
dc.subjectInvasionen_US
dc.titleInterstitial fluid flow in cancer: implications for disease progression and treatmenten_US
dc.typeArticle - Refereeden_US
dc.identifier.urlhttps://www.dovepress.com/interstitial-fluid-flow-in-cancer-implications-for-disease-progression-peer-reviewed-article-CMAR
dc.title.serialCancer Management and Researchen_US
dc.identifier.doihttps://doi.org/10.2147/CMAR.S65444
dc.identifier.volume6en_US
dc.type.dcmitypeText


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