Now showing items 1-3 of 3
Mutual action by Gγ and Gβ for optimal activation of GIRK channels in a channel subunit-specific manner
(Nature Publishing Group, 2019-01-24)
The tetrameric G protein-gated K+ channels (GIRKs) mediate inhibitory effects of neurotransmitters that activate Gi/o-coupled receptors. GIRKs are activated by binding of the Gβγ dimer, via contacts with Gβ. Gγ underlies ...
MeCP2 Deficiency Leads to Loss of Glial Kir4.1
(Society for Neuroscience, 2018)
Rett syndrome is a devastating neurodevelopmental disorder that affects 1 in 10,000–25,000 females. Mutations in methyl-CpG-binding protein 2 (MeCP2), a transcriptional regulator, are responsible for >95% of RTT cases. ...
Glial Dysfunction in MeCP2 Deficiency Models: Implications for Rett Syndrome
Rett syndrome (RTT) is a rare, X-linked neurodevelopmental disorder typically affecting females, resulting in a range of symptoms including autistic features, intellectual impairment, motor deterioration, and autonomic ...