Browsing Scholarly Works, School of Neuroscience by Issue Date
Now showing items 1-20 of 37
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A developmental sex difference in hippocampal neurogenesis is mediated by endogenous Oestradiol
(BMC, 2010)Background: Oestradiol is a steroid hormone that exerts extensive influence on brain development and is a powerful modulator of hippocampal structure and function. The hippocampus is a critical brain region regulating ... -
The role of the FOXP family of transcription factors in ASD
(Hindawi, 2012)Autism spectrum disorders (ASD) is a neurodevelopmental disease with complex genetics; however, the genes that are responsible for this disease still remain mostly unknown. Here, we focus on the FOXP family of transcription ... -
Sex, stress, and epigenetics: regulation of behavior in animal models of mood disorders
(BMC, 2013)Women have a higher incidence of stress related disorders including depression and generalized anxiety disorder, and epigenetic mechanisms likely contribute to this sex difference. Evidence from preclinical research suggests ... -
Functional changes in glutamate transporters and astrocyte biophysical properties in a rodent model of focal cortical dysplasia
(Frontiers, 2014-12-17)Cortical dysplasia is associated with intractable epilepsy and developmental delay in young children. Recent work with the rat freeze-induced focal cortical dysplasia (FCD) model has demonstrated that hyperexcitability in ... -
A Time-Series Model of Phase Amplitude Cross Frequency Coupling and Comparison of Spectral Characteristics with Neural Data
(Hindawi, 2015)Stochastic processes that exhibit cross-frequency coupling (CFC) are introduced. The ability of these processes to model observed CFC in neural recordings is investigated by comparison with published spectra. One of the ... -
Novel Applications of Magnetic Cell Sorting to Analyze Cell-Type Specific Gene and Protein Expression in the Central Nervous System
(PLOS, 2016-02-26)The isolation and study of cell-specific populations in the central nervous system(CNS) has gained significant interest in the neuroscience community. The ability to examine cell-specific gene and protein expression patterns ... -
The Ionotropic Receptors IR21a and IR25a mediate cool sensing in Drosophila
(eLife Sciences Publications, 2016-04-29)Animals rely on highly sensitive thermoreceptors to seek out optimal temperatures, but the molecular mechanisms of thermosensing are not well understood. The Dorsal Organ Cool Cells (DOCCs) of the Drosophila larva are a ... -
Neonatal maternal separation stress elicits lasting DNA methylation changes in the hippocampus of stress-reactive Wistar Kyoto rats
(Wiley-Blackwell, 2016-11-01)Early-life stress (ELS) can alter neurodevelopment in variable ways, ranging from producing deleterious outcomes to stress resilience. While most ELS studies focus on its harmful effects, recent work by our lab and others ... -
Frontal beta-theta network during REM sleep
(eLife Sciences Publications, 2017-01-25)We lack detailed knowledge about the spatio-temporal physiological signatures of REM sleep, especially in humans. By analyzing intracranial electrode data from humans, we demonstrate for the first time that there are ... -
Differential stress induced c-Fos expression and identification of region-specific miRNA-mRNA networks in the dorsal raphe and amygdala of high-responder/low-responder rats
(2017-02)Chronic stress triggers a variety of physical and mental health problems, and how individuals 2 cope with stress influences risk for emotional disorders. To investigate molecular mechanisms 3 underlying distinct stress ... -
Genetic predisposition to high anxiety- and depression-like behavior coincides with diminished DNA methylation in the adult rat amygdala.
(2017-03-01)Understanding biological mechanisms that shape vulnerability to emotional dysfunction is critical for elucidating the neurobiology of psychiatric illnesses like anxiety and depression. To elucidate molecular and epigenetic ... -
Positive Modulatory Interactions of NMDA Receptor GluN1/2B Ligand Binding Domains Attenuate Antagonists Activity
(Frontiers, 2017-05-09)N-methyl D-aspartate receptors (NMDAR) play crucial role in normal brain function and pathogenesis of neurodegenerative and psychiatric disorders. Functional tetra-heteromeric NMDAR contains two obligatory GluN1 subunits ... -
Zika Virus Persistently and Productively Infects Primary Adult Sensory Neurons In Vitro
(MDPI, 2017-10-13)Zika virus (ZIKV) has recently surged in human populations, causing an increase in congenital and Guillain-Barré syndromes. While sexual transmission and presence of ZIKV in urine, semen, vaginal secretions, and saliva ... -
Dual color optogenetic control of neural populations using low-noise, multishank optoelectrodes
(Nature, 2018)Optogenetics allows for optical manipulation of neuronal activity and has been increasingly combined with intracellular and extracellular electrophysiological recordings. Genetically-identified classes of neurons are ... -
Adenosine Signaling through A1 Receptors Inhibits Chemosensitive Neurons in the Retrotrapezoid Nucleus
(Society for Neuroscience, 2018)A subset of neurons in the retrotrapezoid nucleus (RTN) function as respiratory chemoreceptors by regulating depth and frequency of breathing in response to changes in tissue CO2/H. The activity of chemosensitive RTN neurons ... -
MeCP2 Deficiency Leads to Loss of Glial Kir4.1
(Society for Neuroscience, 2018)Rett syndrome is a devastating neurodevelopmental disorder that affects 1 in 10,000–25,000 females. Mutations in methyl-CpG-binding protein 2 (MeCP2), a transcriptional regulator, are responsible for >95% of RTT cases. ... -
Inferring and validating mechanistic models of neural microcircuits based on spike-train data
(Virginia Tech, 2018-02-07)The interpretation of neuronal spike train recordings often relies on abstract statistical models that allow for principled parameter estimation and model selection but provide only limited insights into underlying ...
