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dc.contributor.authorBracey, Daniel N.
dc.contributor.authorSeyler, Thorsten M.
dc.contributor.authorJinnah, Alexander H.
dc.contributor.authorLively, Mark O.
dc.contributor.authorWilley, Jeffrey S.
dc.contributor.authorSmith, Thomas L.
dc.contributor.authorVan Dyke, Mark E.
dc.contributor.authorWhitlock, Patrick W.
dc.date.accessioned2018-09-21T16:41:49Z
dc.date.available2018-09-21T16:41:49Z
dc.date.issued2018-07-12
dc.identifier.citationBracey, D.N.; Seyler, T.M.; Jinnah, A.H.; Lively, M.O.; Willey, J.S.; Smith, T.L.; Van Dyke, M.E.; Whitlock, P.W. A Decellularized Porcine Xenograft-Derived Bone Scaffold for Clinical Use as a Bone Graft Substitute: A Critical Evaluation of Processing and Structure. J. Funct. Biomater. 2018, 9, 45.
dc.identifier.urihttp://hdl.handle.net/10919/85072
dc.description.abstractBackground: Bone grafts are used in approximately one half of all musculoskeletal surgeries. Autograft bone is the historic gold standard but is limited in supply and its harvest imparts significant morbidity to the patient. Alternative sources of bone graft include allografts, synthetics and, less commonly, xenografts which are taken from animal species. Xenografts are available in unlimited supply from healthy animal donors with controlled biology, avoiding the risk of human disease transmission, and may satisfy current demand for bone graft products. Methods: In the current study, cancellous bone was harvested from porcine femurs and subjected to a novel decellularization protocol to derive a bone scaffold. Results: The scaffold was devoid of donor cellular material on histology and DNA sampling (p < 0.01). Microarchitectural properties important for osteoconductive potential were preserved after decellularization as shown by high resolution imaging modalities. Proteomics data demonstrated similar profiles when comparing the porcine bone scaffold against commercially available human demineralized bone matrix approved for clinical use. Conclusion: We are unaware of any porcine-derived bone graft products currently used in orthopaedic surgery practice. Results from the current study suggest that porcine-derived bone scaffolds warrant further consideration to serve as a potential bone graft substitute.
dc.format.mimetypeapplication/pdf
dc.languageen_USen_US
dc.publisherMDPI
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleA Decellularized Porcine Xenograft-Derived Bone Scaffold for Clinical Use as a Bone Graft Substitute: A Critical Evaluation of Processing and Structureen_US
dc.typeArticle - Refereeden_US
dc.date.updated2018-09-21T07:13:11Z
dc.contributor.departmentBiomedical Engineering and Mechanicsen_US
dc.title.serialJournal of Functional Biomaterials
dc.identifier.doihttps://doi.org/10.3390/jfb9030045
dc.type.dcmitypeText


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Creative Commons Attribution 4.0 International
License: Creative Commons Attribution 4.0 International