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dc.contributor.authorLiu, Lingbin
dc.contributor.authorCui, Zhifu
dc.contributor.authorXiao, Qihai
dc.contributor.authorZhang, Haihan
dc.contributor.authorZhao, Xiaoling
dc.contributor.authorWang, Yan
dc.contributor.authorYin, Huadong
dc.contributor.authorLi, Diyan
dc.contributor.authorZhu, Qing
dc.date.accessioned2018-09-24T12:43:50Z
dc.date.available2018-09-24T12:43:50Z
dc.date.issued2018-09-19
dc.identifier.citationLingbin Liu, Zhifu Cui, Qihai Xiao, et al., “Polymorphisms in the Chicken Growth Differentiation Factor 9 Gene Associated with Reproductive Traits,” BioMed Research International, vol. 2018, Article ID 9345473, 11 pages, 2018. doi:10.1155/2018/9345473
dc.identifier.urihttp://hdl.handle.net/10919/85116
dc.description.abstractThe aim of the study was to investigate GDF9 gene polymorphisms and their association with reproductive traits in chicken using DNA sequencing. A total of 279 Dongxiang blue-shelled (DX) chickens and 232 Luhua (LH) chickens were used for validation. We detected 15 single nucleotide polymorphisms (SNPs): nine SNPs were previously unreported in chicken, two were missense mutations, and only three exhibited significant associations with reproductive traits. G.17156387C>T was significantly associated with age at first egg (AFE) and weight of first egg (WFE) in both breeds. Birds carrying the CC genotype exhibited higher AFE and WFE values than those with the TT genotype. The SNP g.17156427A>G exhibited an association with egg weight at 300 days of age (EWTA) in DX but not in LH chickens. The SNP g.17156703A>C affected the AFE and EN (total number of eggs at 300 days of age) in DX chickens. In addition, certain diplotypes significantly affected AFE, BWTA (body weight at 300 days of age), and EN in both breeds. RT-PCR results showed that the GDF9 gene was highly expressed in stroma with cortical follicles (STR) and prehierarchal follicles. These results provided further evidence that the GDF9 gene is involved in determining reproductive traits in chicken.
dc.format.mimetypeapplication/pdf
dc.language.isoenen_US
dc.publisherHindawien_US
dc.rightsCreative Commons Attribution 4.0 International (CC BY 4.0)*
dc.rightsCreative Commons Attribution 4.0 International (CC BY 4.0)*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.titlePolymorphisms in the Chicken Growth Differentiation Factor 9 Gene Associated with Reproductive Traitsen_US
dc.typeArticle - Refereed
dc.date.updated2018-09-23T07:03:30Z
dc.description.versionPeer Reviewed
dc.rights.holderCopyright © 2018 Lingbin Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.title.serialBioMed Research Internationalen_US
dc.identifier.doihttps://doi.org/10.1155/2018/9345473
dc.type.dcmitypeText


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Creative Commons Attribution 4.0 International (CC BY 4.0)
License: Creative Commons Attribution 4.0 International (CC BY 4.0)