Show simple item record

dc.contributor.authorChen, Lien_US
dc.contributor.authorChoyke, Peter L.en_US
dc.contributor.authorWang, Niyaen_US
dc.contributor.authorClarke, Roberten_US
dc.contributor.authorBhujwalla, Zaver M.en_US
dc.contributor.authorHillman, Elizabeth M. C.en_US
dc.contributor.authorWang, Geen_US
dc.contributor.authorWang, Yueen_US
dc.date.accessioned2018-10-03T18:10:23Z
dc.date.available2018-10-03T18:10:23Z
dc.date.issued2014-11-07en_US
dc.identifier.othere112143en_US
dc.identifier.urihttp://hdl.handle.net/10919/85217
dc.description.abstractWith the existence of biologically distinctive malignant cells originated within the same tumor, intratumor functional heterogeneity is present in many cancers and is often manifested by the intermingled vascular compartments with distinct pharmacokinetics. However, intratumor vascular heterogeneity cannot be resolved directly by most in vivo dynamic imaging. We developed multi-tissue compartment modeling (MTCM), a completely unsupervised method of deconvoluting dynamic imaging series from heterogeneous tumors that can improve vascular characterization in many biological contexts. Applying MTCM to dynamic contrast-enhanced magnetic resonance imaging of breast cancers revealed characteristic intratumor vascular heterogeneity and therapeutic responses that were otherwise undetectable. MTCM is readily applicable to other dynamic imaging modalities for studying intratumor functional and phenotypic heterogeneity, together with a variety of foreseeable applications in the clinic.en_US
dc.format.mimetypeapplication/pdfen_US
dc.language.isoen_USen_US
dc.publisherPLOSen_US
dc.rightsCreative Commons Attribution 4.0en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.titleUnsupervised Deconvolution of Dynamic Imaging Reveals Intratumor Vascular Heterogeneity and Repopulation Dynamicsen_US
dc.typeArticle - Refereeden_US
dc.description.versionPeer Revieweden_US
dc.title.serialPLOS ONEen_US
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0112143en_US
dc.identifier.volume9en_US
dc.identifier.issue11en_US
dc.type.dcmitypeTexten_US
dc.identifier.pmid25379705en_US
dc.identifier.eissn1932-6203en_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Creative Commons Attribution 4.0
License: Creative Commons Attribution 4.0