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dc.contributor.authorRajaraman, Rajmohanen
dc.contributor.authorSun, Zhifengen
dc.contributor.authorSundaram, Ravien
dc.contributor.authorVullikanti, Anil Kumar S.en
dc.date.accessioned2018-10-18T16:58:14Zen
dc.date.available2018-10-18T16:58:14Zen
dc.date.issued2013-08-01en
dc.identifier.othere64653en
dc.identifier.urihttp://hdl.handle.net/10919/85412en
dc.description.abstractWe formulated a network-based model to understand how risk behavior change in conjunction with failure of prophylactic interventions can lead to unintended outcomes where “less (intervention) is more (effective).” Our model captures the distinction between one- and two-sided risk behavior change. In one-sided situations (e.g. influenza/H1N1) it is sufficient for either individual in an interaction to exhibit risk behavior change whereas in two-sided situations (e.g. AIDS/HIV) it is necessary for both individuals in the interaction to exhibit risk behavior change, for a potential transmission of the disease. A central discovery is that this phenomenon occurs at differing levels of intervention coverage depending upon the “sidedness” of the interaction. We find that for one-sided interactions, sufficiently high vaccination coverage is necessary for mitigating the effects of risk behavior; for two-sided interactions, it is essential to combine prophylactic treatments with programs aimed at reducing risky behavior. Furthermore, again dependent on the “sidedness,” targeting highly connected nodes can be strictly worse than uniformly random interventions at the same level of coverage.en
dc.format.mimetypeapplication/pdfen
dc.language.isoen_USen
dc.publisherPLOSen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleNetwork Effects of Risk Behavior Change Following Prophylactic Interventionsen
dc.typeArticle - Refereeden
dc.description.versionPeer Revieweden
dc.contributor.departmentComputer Scienceen
dc.contributor.departmentFralin Life Sciences Instituteen
dc.title.serialPLOS ONEen
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0064653en
dc.identifier.volume8en
dc.identifier.issue8en
dc.type.dcmitypeTexten
dc.identifier.pmid23936290en
dc.identifier.eissn1932-6203en


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Creative Commons Attribution 4.0 International
License: Creative Commons Attribution 4.0 International