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dc.contributor.authorSchanen, Brian C.en_US
dc.contributor.authorDas, Soumenen_US
dc.contributor.authorReilly, Christopher M.en_US
dc.contributor.authorWarren, William L.en_US
dc.contributor.authorSelf, William T.en_US
dc.contributor.authorSeal, Sudiptaen_US
dc.contributor.authorDrake, Donald R., IIIen_US
dc.date.accessioned2018-10-19T14:32:36Z
dc.date.available2018-10-19T14:32:36Z
dc.date.issued2013-05-08en_US
dc.identifier.othere62816en_US
dc.identifier.urihttp://hdl.handle.net/10919/85432
dc.description.abstractImmunomodulation by nanoparticles, especially as related to the biochemical properties of these unique materials, has scarcely been explored. In an in vitro model of human immunity, we demonstrate two catalytic nanoparticles, TiO2 (oxidant) and CeO2 (antioxidant), have nearly opposite effects on human dendritic cells and T helper (TH) cells. For example, whereas TiO2 nanoparticles potentiated DC maturation that led towards TH1-biased responses, treatment with antioxidant CeO2 nanoparticles induced APCs to secrete the anti-inflammatory cytokine, IL-10, and induce a TH2-dominated T cell profile. In subsequent studies, we demonstrate these results are likely explained by the disparate capacities of the nanoparticles to modulate ROS, since TiO2, but not CeO2 NPs, induced inflammatory responses through an ROS/inflammasome/IL-1β pathway. This novel capacity of metallic NPs to regulate innate and adaptive immunity in profoundly different directions via their ability to modulate dendritic cell function has strong implications for human health since unintentional exposure to these materials is common in modern societies.en_US
dc.format.mimetypeapplication/pdfen_US
dc.language.isoen_USen_US
dc.publisherPLOSen_US
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleImmunomodulation and T Helper TH1/TH2 Response Polarization by CeO2 and TiO2 Nanoparticlesen_US
dc.typeArticle - Refereeden_US
dc.description.versionPeer Revieweden_US
dc.title.serialPLOS ONEen_US
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0062816en_US
dc.identifier.volume8en_US
dc.identifier.issue5en_US
dc.type.dcmitypeTexten_US
dc.identifier.pmid23667525en_US
dc.identifier.eissn1932-6203en_US


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Creative Commons Attribution 4.0 International
License: Creative Commons Attribution 4.0 International