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dc.contributor.authorLebovitz, Yeonwooen
dc.contributor.authorRingel-Scaia, Veronica M.en
dc.contributor.authorAllen, Irving C.en
dc.contributor.authorTheus, Michelle H.en
dc.description.abstractFrom immunology to neuroscience, interactions between the microbiome and host are increasingly appreciated as potent drivers of health and disease. Epidemiological studies previously identified compelling correlations between perinatalmicrobiome insults and neurobehavioral outcomes, the mechanistic details of which are just beginning to take shape thanks to germ-free and antibiotics-based animal models. This review summarizes parallel developments from clinical and preclinical research that suggest neuroactive roles for gut bacteria and their metabolites. We also examine the nascent field of microbiome-microglia crosstalk research, which includes pharmacological and genetic strategies to inform functional capabilities of microglia in response to microbial programming. Finally, we address an emerging hypothesis behind neurodevelopmental disorders, which implicates microbiome dysbiosis in the atypical programming of neuroimmune cells, namely microglia.en
dc.description.sponsorshipThe authors acknowledge funding from the National Institutes of Health DK105975 (IA), NS096281 (MT), and NS081623 (MT); Virginia-Maryland College of Veterinary Medicine & Via College of Osteopathic Medicine Center for One Health Research Grant (MT, IA); Virginia-Maryland College of Veterinary Medicine Internal Research Competition (IA). Yeonwoo Lebovitz is supported through Virginia Tech Interdisciplinary Graduate Education Program in Regenerative Medicine and the Dannon Yogurt, Probiotics and the Gut Microbiome Fellowship Grant. VR-S is supported through the American Association of Immunologists Careers in Immunology Fellowship Program. Publication costs were supported by Virginia Tech Open Access Subvention Fund. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIHor any other funding agency.We apologize to any colleagues whose work was not included due to length constraints.en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.subjectbacterial metabolitesen
dc.subjectgut bacteriaen
dc.titleEmerging Developments in Microbiome and Microglia Research: Implications for Neurodevelopmental Disordersen
dc.typeArticle - Refereeden
dc.title.serialFrontiers in Immunologyen

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Creative Commons Attribution 4.0 International
License: Creative Commons Attribution 4.0 International