Show simple item record

dc.contributor.authorBrooks, Justin M.
dc.contributor.authorSu, Jianmin
dc.contributor.authorLevy, Carl
dc.contributor.authorWang, Jessica S.
dc.contributor.authorSeabrook, Tania A.
dc.contributor.authorGuido, William
dc.date.accessioned2018-11-19T18:32:02Z
dc.date.available2018-11-19T18:32:02Z
dc.date.issued2013-11-14
dc.identifier.urihttp://hdl.handle.net/10919/85884
dc.description.abstractNeural circuit formation demands precise timing of innervation by different classes of axons. However, the mechanisms underlying such activity remain largely unknown. In the dorsal lateral geniculate nucleus (dLGN), axons from the retina and visual cortex innervate thalamic relay neurons in a highly coordinated manner, with those from the cortex arriving well after those from retina. The differential timing of retino- and corticogeniculate innervation is not a coincidence but is orchestrated by retinal inputs. Here, we identified a chondroitin sulfate proteoglycan (CSPG) that regulates the timing of corticogeniculate innervation. Aggrecan, a repulsive CSPG, is enriched in neonatal dLGN and inhibits cortical axons from prematurely entering the dLGN. Postnatal loss of aggrecan from dLGN coincides with upregulation of aggrecanase expression in the dLGN and corticogeniculate innervation and, it is important to note, is regulated by retinal inputs. Taken together, these studies reveal a molecular mechanism through which one class of axons coordinates the temporal targeting of another class of axons.
dc.description.sponsorshipNational Institutes of Health
dc.description.sponsorshipNIH: EY012716
dc.description.sponsorshipNIH: EY021222
dc.language.isoen_US
dc.publisherElsevier
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleA Molecular Mechanism Regulating the Timing of Corticogeniculate Innervation
dc.typeArticle - Refereed
dc.title.serialCell Reports
dc.identifier.doihttps://doi.org/10.1016/j.celrep.2013.09.041
dc.identifier.volume5
dc.identifier.issue3
dc.type.dcmitypetext


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International
License: Attribution 4.0 International