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dc.contributor.authorSingh, Manjoten_US
dc.date.accessioned2018-12-01T07:01:05Z
dc.date.available2018-12-01T07:01:05Z
dc.date.issued2017-06-08en_US
dc.identifier.othervt_gsexam:11948en_US
dc.identifier.urihttp://hdl.handle.net/10919/86202
dc.description.abstractThe inability to monitor the molecular trajectories of whole organs throughout the clinically relevant ischemic interval is a critical problem underlying the organ shortage crisis. Here, we report a novel technique for fabricating manufacturing conformal microfluidic devices for organ interface. 3D conformal printing was leveraged to engineer and fabricate novel organ-conforming microfluidic devices that endow the interface between microfluidic channels and the organ cortex. Large animal studies reveal microfluidic biopsy samples contain rich diagnostic information, including clinically relevant biomarkers of ischemic pathophysiology. Overall, these results suggest microfluidic biopsy via 3D printed organ-conforming microfluidic devices could shift the paradigm for whole organ preservation and assessment, thereby relieving the organ shortage crisis through increased availability and quality of donor organs.en_US
dc.format.mediumETDen_US
dc.publisherVirginia Techen_US
dc.rightsThis item is protected by copyright and/or related rights. Some uses of this item may be deemed fair and permitted by law even without permission from the rights holder(s), or the rights holder(s) may have licensed the work for use under certain conditions. For other uses you need to obtain permission from the rights holder(s).en_US
dc.subjectbiomanufacturingen_US
dc.subjectmicrofluidicsen_US
dc.subject3D printingen_US
dc.subjectorgan health assessmenten_US
dc.titleConformal Additive Manufacturing for Organ Interfaceen_US
dc.typeThesisen_US
dc.contributor.departmentIndustrial and Systems Engineeringen_US
dc.description.degreeMaster of Scienceen_US
thesis.degree.nameMaster of Scienceen_US
thesis.degree.levelmastersen_US
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen_US
thesis.degree.disciplineIndustrial and Systems Engineeringen_US
dc.contributor.committeechairJohnson, Blakeen_US
dc.contributor.committeememberKong, Zhenyuen_US
dc.contributor.committeememberRobertson, John L.en_US


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