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dc.contributor.authorHubbard, W. Brad
dc.contributor.authorLashof-Sullivan, Margaret
dc.contributor.authorGreenberg, Shaylen
dc.contributor.authorNorris, Carly
dc.contributor.authorEck, Joseph
dc.contributor.authorLavik, Erin
dc.contributor.authorVandeVord, Pamela
dc.date.accessioned2018-12-12T20:05:53Z
dc.date.available2018-12-12T20:05:53Z
dc.date.issued2018-07-13
dc.identifier.issn2045-2322
dc.identifier.other10622
dc.identifier.urihttp://hdl.handle.net/10919/86353
dc.description.abstractExplosions account for 79% of combat related injuries and often lead to polytrauma, a majority of which include blast-induced traumatic brain injuries (bTBI). These injuries lead to internal bleeding in multiple organs and, in the case of bTBI, long term neurological deficits. Currently, there are no treatments for internal bleeding beyond fluid resuscitation and surgery. There is also a dearth of treatments for TBI. We have developed a novel approach using hemostatic nanoparticles that encapsulate an anti-inflammatory, dexamethasone, to stop the bleeding and reduce inflammation after injury. We hypothesize that this will improve not only survival but long term functional outcomes after blast polytrauma. Poly(lactic-co-glycolic acid) hemostatic nanoparticles encapsulating dexamethasone (hDNPs) were fabricated and tested following injury along with appropriate controls. Rats were exposed to a single blast wave using an Advanced Blast Simulator, inducing primary blast lung and bTBI. Survival was elevated in the hDNPs group compared to controls. Elevated anxiety parameters were found in the controls, compared to hDNPs. Histological analysis indicated that apoptosis and blood-brain barrier disruption in the amygdala were significantly increased in the controls compared to the hDNPs and sham groups. Immediate intervention is crucial to mitigate injury mechanisms that contribute to emotional deficits.en_US
dc.description.sponsorshipDOD CDMRP Program [W81XWH-11-1-0014]; NIH Director's New Innovator Award [DP20D007338]
dc.format.extent12 pages
dc.format.mimetypeapplication/pdf
dc.language.isoen_US
dc.publisherSpringer Nature
dc.rightsCreative Commons Attribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectblood-brain-barrier
dc.subjectposttraumatic-stress-disorder
dc.subjectpsychiatric-disorders
dc.subjectoxidative stress
dc.subjectlung injury
dc.subjectspinal-cord
dc.subjectmouse model
dc.subjecttime-course
dc.subjectopen-field
dc.subjectrat model
dc.titleHemostatic nanoparticles increase survival, mitigate neuropathology and alleviate anxiety in a rodent blast trauma modelen_US
dc.typeArticle - Refereed
dc.description.notesWe would like to thank Dr. Michael Urban, Dr. Zachary Bailey, Bryce Dunn, and Ryan Brady for their technical assistance during blast testing. We would like to acknowledge funding support by the DOD CDMRP Program W81XWH-11-1-0014 and the NIH Director's New Innovator Award number DP20D007338 (EL).
dc.title.serialScientific Reports
dc.identifier.doihttps://doi.org/10.1038/s41598-018-28848-2
dc.identifier.volume8
dc.type.dcmitypeText
dc.identifier.pmid30006635


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Creative Commons Attribution 4.0 International
License: Creative Commons Attribution 4.0 International