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dc.contributor.authorLatouche, Eduardo L.
dc.contributor.authorArena, Christopher B.
dc.contributor.authorIvey, Jill W.
dc.contributor.authorGarcia, Paulo A.
dc.contributor.authorPancotto, Theresa E.
dc.contributor.authorPavlisko, Noah
dc.contributor.authorVerbridge, Scott
dc.contributor.authorDavalos, Rafael V.
dc.contributor.authorRossmeisl, John H.
dc.date.accessioned2019-01-31T16:06:37Z
dc.date.available2019-01-31T16:06:37Z
dc.date.issued2018
dc.identifier.urihttp://hdl.handle.net/10919/87096
dc.description.abstractHigh-frequency irreversible electroporation is a nonthermal method of tissue ablation that uses bursts of 0.5- to 2.0-microsecond bipolar electric pulses to permeabilize cell membranes and induce cell death. High-frequency irreversible electroporation has potential advantages for use in neurosurgery, including the ability to deliver pulses without inducing muscle contraction, inherent selectivity against malignant cells, and the capability of simultaneously opening the blood–brain barrier surrounding regions of ablation. Our objective was to determine whether high-frequency irreversible electroporation pulses capable of tumor ablation could be delivered to dogs with intracranial meningiomas. Three dogs with intracranial meningiomas were treated. Patient-specific treatment plans were generated using magnetic resonance imaging-based tissue segmentation, volumetric meshing, and finite element modeling. Following tumor biopsy, high-frequency irreversible electroporation pulses were stereotactically delivered in situ followed by tumor resection and morphologic and volumetric assessments of ablations. Clinical evaluations of treatment included pre- and posttreatment clinical, laboratory, and magnetic resonance imaging examinations and adverse event monitoring for 2 weeks posttreatment. High-frequency irreversible electroporation pulses were administered successfully in all patients. No adverse events directly attributable to high-frequency irreversible electroporation were observed. Individual ablations resulted in volumes of tumor necrosis ranging from 0.25 to 1.29 cm3. In one dog, nonuniform ablations were observed, with viable tumor cells remaining around foci of intratumoral mineralization. In conclusion, high-frequency irreversible electroporation pulses can be delivered to brain tumors, including areas adjacent to critical vasculature, and are capable of producing clinically relevant volumes of tumor ablation. Mineralization may complicate achievement of complete tumor ablation.en_US
dc.description.sponsorshipThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was funded by the Virginia Biosciences Health Research Corporation, “The Catalyst.”
dc.format.extent10 pages
dc.format.mimetypeapplication/pdf
dc.language.isoen_US
dc.publisherSage
dc.rightsCreative Commons Attribution-NonCommercial 4.0
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectanimal models
dc.subjectbrain tumor
dc.subjectdog
dc.subjectneuro-oncology
dc.subjectpulsed electric fields
dc.titleHigh-Frequency Irreversible Electroporation for Intracranial Meningioma: A Feasibility Study in a Spontaneous Canine Tumor Modelen_US
dc.typeArticle - Refereed
dc.title.serialTechnology in Cancer Research & Treatment
dc.identifier.doihttps://doi.org/10.1177/1533033818785285
dc.identifier.volume17
dc.type.dcmitypeText


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