Show simple item record

dc.contributor.authorJirimutu
dc.contributor.authorWang, Zhen
dc.contributor.authorDing, Guohui
dc.contributor.authorChen, Gangliang
dc.contributor.authorSun, Yamin
dc.contributor.authorSun, Zhihong
dc.contributor.authorZhang, Heping
dc.contributor.authorWang, Lei
dc.contributor.authorHasi, Surong
dc.contributor.authorZhang, Yan
dc.contributor.authorLi, Jianmei
dc.contributor.authorShi, Yixiang
dc.contributor.authorXu, Ze
dc.contributor.authorHe, Chuan
dc.contributor.authorYu, Siriguleng
dc.contributor.authorLi, Shengdi
dc.contributor.authorZhang, Wenbin
dc.contributor.authorBatmunkh, Mijiddorj
dc.contributor.authorTs, Batsukh
dc.contributor.authorNarenbatu
dc.contributor.authorUnierhu
dc.contributor.authorBat-Ireedui, Shirzana
dc.contributor.authorGao, Hongwei
dc.contributor.authorBaysgalan, Banzragch
dc.contributor.authorLi, Qing
dc.contributor.authorJia, Zhiling
dc.contributor.authorTurigenbayila
dc.contributor.authorSubudenggerile
dc.contributor.authorNarenmanduhu
dc.contributor.authorWang, Zhaoxia
dc.contributor.authorWang, Juan
dc.contributor.authorPan, Lei
dc.contributor.authorChen, Yongcan
dc.contributor.authorGanerdene, Yaichil
dc.contributor.authorDabxilt
dc.contributor.authorErdemt
dc.contributor.authorAltansha
dc.contributor.authorAltansukh
dc.contributor.authorLiu, Tuya
dc.contributor.authorCao, Minhui
dc.contributor.authorAruuntsever
dc.contributor.authorBayart
dc.contributor.authorHosblig
dc.contributor.authorHe, Fei
dc.contributor.authorZha-ti, A.
dc.contributor.authorZheng, Guangyong
dc.contributor.authorQiu, Feng
dc.contributor.authorSun, Zikui
dc.contributor.authorZhao, Lele
dc.contributor.authorZhao, Wenjing
dc.contributor.authorLiu, Baohong
dc.contributor.authorLi, Chao
dc.contributor.authorChen, Yunqin
dc.contributor.authorTang, Xiaoyan
dc.contributor.authorGuo, Chunyan
dc.contributor.authorLiu, Wei
dc.contributor.authorMing, Liang
dc.contributor.authorTemuulen
dc.contributor.authorCui, Aiying
dc.contributor.authorLi, Yi
dc.contributor.authorGao, Junhui
dc.contributor.authorLi, Jing
dc.contributor.authorWurentaodi
dc.contributor.authorNiu, Shen
dc.contributor.authorSun, Tao
dc.contributor.authorZhai, Zhengxiao
dc.contributor.authorZhang, Min
dc.contributor.authorChen, Chen
dc.contributor.authorBaldan, Tunteg
dc.contributor.authorBayaer, Tuman
dc.contributor.authorLi, Yixue
dc.contributor.authorMeng, He
dc.date.accessioned2019-02-19T14:53:30Z
dc.date.available2019-02-19T14:53:30Z
dc.date.issued2012-11
dc.identifier.issn2041-1723
dc.identifier.other1202
dc.identifier.urihttp://hdl.handle.net/10919/87718
dc.description.abstractBactrian camels serve as an important means of transportation in the cold desert regions of China and Mongolia. Here we present a 2.01 Gb draft genome sequence from both a wild and a domestic bactrian camel. We estimate the camel genome to be 2.38 Gb, containing 20,821 protein-coding genes. Our phylogenomics analysis reveals that camels shared common ancestors with other even-toed ungulates about 55-60 million years ago. Rapidly evolving genes in the camel lineage are significantly enriched in metabolic pathways, and these changes may underlie the insulin resistance typically observed in these animals. We estimate the genome-wide heterozygosity rates in both wild and domestic camels to be 1.0 x 10(-3). However, genomic regions with significantly lower heterozygosity are found in the domestic camel, and olfactory receptors are enriched in these regions. Our comparative genomics analyses may also shed light on the genetic basis of the camel's remarkable salt tolerance and unusual immune system.en_US
dc.description.sponsorshipState key basic research programme (973) [2011CB910204, 2010CB529206, 2011CBA00801]
dc.description.sponsorshipResearch Programme of CAS [KSCX2-EW-R-04, KSCX2-YW-R-190, 2011KIP204]
dc.description.sponsorshipNational Natural Science Foundation of China [30900272, 31070752]
dc.description.sponsorshipChinese Ministry for Science and Technology [2008BAI64B01]
dc.description.sponsorshipChinese High-Tech R&D Programme (863) [2009AA02Z304]
dc.description.sponsorshipSA-SIBS Scholarship Programme
dc.format.mimetypeapplication/pdf
dc.language.isoen_US
dc.publisherSpringer Nature
dc.rightsCreative Commons Attribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleGenome sequences of wild and domestic bactrian camelsen_US
dc.typeArticle - Refereed
dc.description.notesWe are indebted to many people whose names are not included in the author list, but who contributed to this project. We thank the Ministry of Environment and Sources of Mongolia for permitting sample collections from wild bactrian camels. This work was supported by State key basic research programme (973) (2011CB910204, 2010CB529206, 2011CBA00801), Research Programme of CAS (KSCX2-EW-R-04, KSCX2-YW-R-190, 2011KIP204), National Natural Science Foundation of China (30900272, 31070752), Chinese Ministry for Science and Technology Grant 2008BAI64B01, Chinese High-Tech R&D Programme (863) (2009AA02Z304) and SA-SIBS Scholarship Programme.
dc.title.serialNature Communications
dc.identifier.doihttps://doi.org/10.1038/ncomms2192
dc.identifier.volume3
dc.type.dcmitypeText
dc.identifier.pmid23149746


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Creative Commons Attribution 4.0 International
License: Creative Commons Attribution 4.0 International