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    Live attenuated chimeric porcine circovirus vaccine

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    Downloads: 19
    Date
    2018-01-02
    Inventor
    Meng, Xiang-Jin
    Beach, Nathan M.
    Ramamoorthy, Sheela
    Metadata
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    Abstract
    The present invention provides a novel chimeric porcine circovirus infectious DNA clone and live attenuated chimeric virus with the PCV2, preferably of subtype PCV2b, capsid gene integrated into a non-pathogenic PCV1 virus genome. In a particular embodiment, the PCV2 capids gene is of subtype PCV2b, the predominant subtype circulating in pigs worldwide. The attenuated chimeric virus, designated PCV1-2b, effectively protects pigs from PCV2b challenges, and can be used as a live vaccine, as well as an inactivated (killed) vaccine, that provides protection and cross protection against PCV2b and PCV2a subtypes infection. The live attenuated vaccine of the present invention is also effective protecting pigs from porcine circovirus-associated disease (PCVAD).
    URI
    http://hdl.handle.net/10919/87827
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    • Scholarly Works, Virginia-Maryland College of Veterinary Medicine [100]
    • Virginia Tech Patents [619]

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