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dc.contributor.authorYang, Lingyu
dc.contributor.authorLiu, Shuyun
dc.contributor.authorDing, Jinmei
dc.contributor.authorDai, Ronghua
dc.contributor.authorHe, Chuan
dc.contributor.authorXu, Ke
dc.contributor.authorHonaker, Christa F.
dc.contributor.authorZhang, Yan
dc.contributor.authorSiegel, Paul
dc.contributor.authorMeng, He
dc.date.accessioned2019-03-14T14:19:49Z
dc.date.available2019-03-14T14:19:49Z
dc.date.issued2017-07-04
dc.identifier.issn1664-302X
dc.identifier.urihttp://hdl.handle.net/10919/88443
dc.description.abstractTo explore coevolution between the gut microbiota and the humoral immune system of the host, we used chickens as the model organism. The host populations were two lines (HAS and LAS) developed from a common founder that had undergone 40 generations of divergent selection for antibody titers to sheep red blood cells (SRBC) and two relaxed sublines (HAR and LAR). Analysis revealed that microevolution of host humoral immunity contributed to the composition of gut microbiota at the taxa level. Relaxing selection enriched some microorganisms whose functions were opposite to host immunity. Particularly, Ruminococcaceae and Oscillospira enriched in high antibody relaxed (HAR) and contributed to reduction in antibody response, while Lactobacillus increased in low antibody relaxed (LAR) and elevated the antibody response. Microbial functional analysis showed that alterations were involved in pathways relating to the immune system and infectious diseases. Our findings demonstrated co-microevolution relationships of host-microbiota and that gut microorganisms influenced host immunity.en_US
dc.format.mimetypeapplication/pdf
dc.language.isoen_US
dc.publisherFrontiers
dc.rightsCreative Commons Attribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleGut Microbiota Co-microevolution with Selection for Host Humoral Immunityen_US
dc.typeArticle - Refereed
dc.title.serialFrontiers in Microbiology
dc.identifier.doihttps://doi.org/10.3389/fmicb.2017.01243
dc.identifier.volume8
dc.type.dcmitypeText
dc.identifier.pmid28725219


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Creative Commons Attribution 4.0 International
License: Creative Commons Attribution 4.0 International