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dc.contributor.authorZhou, C. E.en
dc.contributor.authorSmith, J.en
dc.contributor.authorLam, M.en
dc.contributor.authorZemla, A.en
dc.contributor.authorDyer, Matthew D.en
dc.contributor.authorSlezak, Tomen
dc.date.accessioned2019-04-19T18:32:02Zen
dc.date.available2019-04-19T18:32:02Zen
dc.date.issued2007-01en
dc.identifier.issn0305-1048en
dc.identifier.urihttp://hdl.handle.net/10919/89064en
dc.description.abstractKnowledge of toxins, virulence factors and antibiotic resistance genes is essential for bio-defense applications aimed at identifying 'functional' signatures for characterizing emerging or engineered pathogens. Whereas genetic signatures identify a pathogen, functional signatures identify what a pathogen is capable of. To facilitate rapid identification of sequences and characterization of genes for signature discovery, we have collected all publicly available (as of this writing), organized sequences representing known toxins, virulence factors, and antibiotic resistance genes in one convenient database, which we believe will be of use to the bio-defense research community. MvirDB integrates DNA and protein sequence information from Tox-Prot, SCORPION, the PRINTS virulence factors, VFDB, TVFac, Islander, ARGO and a subset of VIDA. Entries in MvirDB are hyperlinked back to their original sources. A blast tool allows the user to blast against all DNA or protein sequences in MvirDB, and a browser tool allows the user to search the database to retrieve virulence factor descriptions, sequences, and classifications, and to download sequences of interest. MvirDB has an automated weekly update mechanism. Each protein sequence in MvirDB is annotated using our fully automated protein annotation system and is linked to that system's browser tool. MvirDB can be accessed at http://mvirdb.llnl.gov/.en
dc.format.mimetypeapplication/pdfen
dc.language.isoen_USen
dc.rightsCreative Commons Attribution-NonCommercial 2.0 Genericen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/2.0/en
dc.subjectgenomeen
dc.titleMvirDB - a microbial database of protein toxins, virulence factors and antibiotic resistance genes for bio-defence applicationsen
dc.typeArticle - Refereeden
dc.title.serialNucleic Acids Researchen
dc.identifier.doihttps://doi.org/10.1093/nar/gkl791en
dc.identifier.volume35en
dc.type.dcmitypeTexten
dc.identifier.pmid17090593en
dc.identifier.eissn1362-4962en


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