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dc.contributor.authorWilkinson, Ashley Reneen_US
dc.date.accessioned2019-06-11T08:01:27Z
dc.date.available2019-06-11T08:01:27Z
dc.date.issued2019-06-10
dc.identifier.othervt_gsexam:19781en_US
dc.identifier.urihttp://hdl.handle.net/10919/89916
dc.description.abstractPlatelet function in dogs with chronic liver disease Ashley R. Wilkinson Background: Dogs with acquired chronic liver disease often have hemostatic derangements. It is currently unknown whether dogs with acquired chronic liver disease have decreased platelet function and alterations in von Willebrand factor (vWF) that may contribute to hemostatic abnormalities. Hypothesis: Dogs with chronic liver disease have prolonged platelet closure time (CT), assessed with the PFA-100®, and buccal mucosal bleeding time (BMBT), and increased vWF concentration compared to healthy dogs. Animals: Eighteen dogs with chronic acquired liver disease undergoing ultrasound-guided needle biopsy of the liver or laparoscopic liver biopsy and eighteen healthy age-matched control dogs. Methods: Prospective study. BMBT, CT using the PFA-100®, and vWF antigen were measured in dogs with chronic liver enzyme elevation undergoing ultrasound-guided needle biopsy of the liver or laparoscopic liver biopsy. After undergoing ultrasound-guided needle biopsy, dogs were monitored for hemorrhage with serial packed cell volume measurements and focused assessment with sonography. An unpaired t-test was used for normally distributed data and the Mann-Whitney test was used when non-Gaussian distribution was present. The level of significance was set at P <0.05. Results: The CT was not different between the two groups (P = 0.27). The BMBT was significantly longer in the liver disease group compared to the control group (P = 0.019). There was no difference in the mean vWF antigen of the two groups (P = 0.077). Conclusions and clinical relevance: These results demonstrate mild impairment of primary hemostasis in dogs with chronic liver disease based on prolongation of BMBT.en_US
dc.format.mediumETDen_US
dc.publisherVirginia Techen_US
dc.rightsThis item is protected by copyright and/or related rights. Some uses of this item may be deemed fair and permitted by law even without permission from the rights holder(s), or the rights holder(s) may have licensed the work for use under certain conditions. For other uses you need to obtain permission from the rights holder(s).en_US
dc.subjectPlatelet functionen_US
dc.subjectliver diseaseen_US
dc.subjectchronic hepatitisen_US
dc.subjectPFA-100en_US
dc.subjectclosure timeen_US
dc.subjectbuccal mucosal bleeding timeen_US
dc.subjectvon Willebrand factoren_US
dc.subjectliver biopsyen_US
dc.titlePlatelet Function in Dogs with Chronic Liver Diseaseen_US
dc.typeThesisen_US
dc.contributor.departmentBiomedical and Veterinary Sciencesen_US
dc.description.degreeMaster of Scienceen_US
thesis.degree.nameMaster of Scienceen_US
thesis.degree.levelmastersen_US
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen_US
thesis.degree.disciplineBiomedical and Veterinary Sciencesen_US
dc.contributor.committeechairPanciera, David Lawrenceen_US
dc.contributor.committeememberBoes, Katie Maeen_US
dc.contributor.committeememberDemonaco, Stefanieen_US
dc.contributor.committeememberLeib, Michael S.en_US


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