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dc.contributor.authorSorrentino, Darioen
dc.contributor.authorNguyen, Vu Q.en
dc.contributor.authorChitnavis, Maithili V.en
dc.identifier.citationSorrentino, D.; Nguyen, V.Q.; Chitnavis, M.V. Capturing the Biologic Onset of Inflammatory Bowel Diseases: Impact on Translational and Clinical Science. Cells 2019, 8, 548.en
dc.description.abstractWhile much progress has been made in the last two decades in the treatment and the management of inflammatory bowel diseases (IBD)—both ulcerative colitis (UC) and Crohn’s Disease (CD)—as of today these conditions are still diagnosed only after they have become symptomatic. This is a major drawback since by then the inflammatory process has often already caused considerable damage and the disease might have become partially or totally unresponsive to medical therapy. Late diagnosis in IBD is due to the lack of accurate, non-invasive indicators that would allow disease identification during the pre-clinical stage—as it is often done in many other medical conditions. Here, we will discuss what is known about the biologic onset and pre-clinical CD with an emphasis on studies conducted in patients’ first degree relatives. We will then review the possible strategies to diagnose IBD very early in time including screening, available disease markers and imaging, and the possible clinical implications of treating these conditions at or close to their biologic onset. Later, we will review the potential impact of conducting translational research in IBD during the pre-clinical stage, especially focusing on the role of the microbiome in disease etiology and pathogenesis. Finally, we will highlight possible future developments in the field and how they can impact IBD management and our scientific knowledge of these conditions.en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.subjectpre-clinical diseaseen
dc.subjectCrohn’s diseaseen
dc.subjectulcerative colitisen
dc.subjectbiologic onseten
dc.subjectdisease markersen
dc.subjectearly diagnosisen
dc.titleCapturing the Biologic Onset of Inflammatory Bowel Diseases: Impact on Translational and Clinical Scienceen
dc.typeArticle - Refereeden
dc.description.versionPublished versionen

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Creative Commons Attribution 4.0 International
License: Creative Commons Attribution 4.0 International