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dc.contributor.authorGorick, Catherine M.en
dc.contributor.authorChappell, John C.en
dc.contributor.authorPrice, Richard J.en
dc.date.accessioned2019-07-08T11:50:08Zen
dc.date.available2019-07-08T11:50:08Zen
dc.date.issued2019-06-24en
dc.identifier.citationGorick, C.M.; Chappell, J.C.; Price, R.J. Applications of Ultrasound to Stimulate Therapeutic Revascularization. Int. J. Mol. Sci. 2019, 20, 3081.en
dc.identifier.urihttp://hdl.handle.net/10919/91202en
dc.description.abstractMany pathological conditions are characterized or caused by the presence of an insufficient or aberrant local vasculature. Thus, therapeutic approaches aimed at modulating the caliber and/or density of the vasculature by controlling angiogenesis and arteriogenesis have been under development for many years. As our understanding of the underlying cellular and molecular mechanisms of these vascular growth processes continues to grow, so too do the available targets for therapeutic intervention. Nonetheless, the tools needed to implement such therapies have often had inherent weaknesses (i.e., invasiveness, expense, poor targeting, and control) that preclude successful outcomes. Approximately 20 years ago, the potential for using ultrasound as a new tool for therapeutically manipulating angiogenesis and arteriogenesis began to emerge. Indeed, the ability of ultrasound, especially when used in combination with contrast agent microbubbles, to mechanically manipulate the microvasculature has opened several doors for exploration. In turn, multiple studies on the influence of ultrasound-mediated bioeffects on vascular growth and the use of ultrasound for the targeted stimulation of blood vessel growth via drug and gene delivery have been performed and published over the years. In this review article, we first discuss the basic principles of therapeutic ultrasound for stimulating angiogenesis and arteriogenesis. We then follow this with a comprehensive cataloging of studies that have used ultrasound for stimulating revascularization to date. Finally, we offer a brief perspective on the future of such approaches, in the context of both further research development and possible clinical translation.en
dc.format.mimetypeapplication/pdfen
dc.language.isoenen
dc.publisherMDPIen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectarteriogenesisen
dc.subjecttherapeutic revascularizationen
dc.subjectultrasounden
dc.subjectmicrobubblesen
dc.subjectbiomaterialsen
dc.subjectdrug and gene deliveryen
dc.titleApplications of Ultrasound to Stimulate Therapeutic Revascularizationen
dc.typeArticle - Refereeden
dc.date.updated2019-06-28T06:37:59Zen
dc.description.versionPublished versionen
dc.title.serialInternational Journal of Molecular Scienceen
dc.identifier.doihttps://doi.org/10.3390/ijms20123081en
dc.type.dcmitypeTexten


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