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Now showing items 1-20 of 35

    • Activation of PAD4 in NET formation. 

      Rohrbach, Amanda S.; Slade, Daniel J.; Thompson, Paul R.; Mowen, Kerri A. (2012)
      Peptidylarginine deiminases, or PADs, convert arginine residues to the non-ribosomally encoded amino acid citrulline in a variety of protein substrates. PAD4 is expressed in granulocytes and is essential for the formation ...
    • Antimalarial 5,6-Dihydro-alpha-pyrones from Cryptocarya rigidifolia: Related Bicyclic Tetrahydro-alpha-Pyrones Are Artifacts 

      Liu, Yixi; Rakotondraibe, L. Harinantenaina; Brodie, Peggy J.; Wiley, Jessica D.; Cassera, Maria B.; Miller, James S.; Ratovoson, F.; Rakotobe, Etienne; Rasamison, Vincent E.; Kingston, David G. I. (Amer Chemical Soc, 2015-06-01)
    • Antiproliferative Compounds from Cleistanthus boivinianus from the Madagascar Dry Forest 

      Liu, Yixi; Young, Kelly; Rakotondraibe, L. Harinantenaina; Brodie, Peggy J.; Wiley, Jessica D.; Cassera, Maria B.; Callmander, Martin W.; Rakotondrajaona, R.; Rakotobe, Etienne; Rasamison, Vincent E.; TenDyke, Karen; Shen, Yongchun; Kingston, David G. I. (Amer Chemical Soc, 2015-07-01)
    • Antiproliferative triterpenoid saponins from Leptaulus citroides Baill. from the Madagascar rain forest 

      Su, Qingxi; Brodie, Peggy J.; Liu, Yixi; Miller, James S.; Andrianjafy, Naina M.; Antsiferana, Rabodo; Rasamison, Vincent E.; Kingston, David G. I. (Springer, 2016)
      Bioassay-guided fractionation of EtOH extracts obtained from the roots and wood of the Madagascan plant Leptaulus citroides Baill. (Cardiopteridaceae) led to the isolation of ethyl esters of three new triterpenoid saponins ...
    • The cardiolipin-binding peptide elamipretide mitigates fragmentation of cristae networks following cardiac ischemia reperfusion in rats 

      Allen, Mitchell E.; Pennington, Edward Ross; Perry, Justin B.; Dadoo, Sahil; Makrecka-Kuka, Marina; Dambrova, Maija; Moukdar, Fatiha; Patel, Hetal D.; Han, Xianlin; Kidd, Grahame K.; Benson, Emily K.; Raisch, Tristan B.; Poelzing, Steven; Brown, David A.; Shaikh, Saame Raza (2020-07-17)
      Allen and Pennington et al. show that the cardiolipin-binding peptide elamipretide mitigates disease-induced fragmentation of cristae networks following cardiac ischemia reperfusion in rats. This study suggests that ...
    • Characterization of the Ornithine Hydroxylation Step in Albachelin Biosynthesis 

      Bufkin, Kendra; Sobrado, Pablo (MDPI, 2017-10-01)
      N-Hydroxylating monooxygenases (NMOs) are involved in siderophore biosynthesis. Siderophores are high affinity iron chelators composed of catechol and hydroxamate functional groups that are synthesized and secreted ...
    • Chemical and Biological Methods to Detect Post-Translational Modifications of Arginine 

      Slade, Daniel J.; Subramanian, Venkataraman; Fuhrmann, Jakob; Thompson, Paul R. (2014-02)
      Posttranslational modifications (PTMs) of protein embedded arginines are increasingly being recognized as playing an important role in both prokaryotic and eukaryotic biology, and it is now clear that these PTMs modulate ...
    • Chemical Proteomic Platform To Identify Citrullinated Proteins 

      Lewallen, Daniel M.; Bicker, Kevin L.; Subramanian, Venkataraman; Clancy, Kathleen W.; Slade, Daniel J.; Martell, Julianne; Dreyton, Christina J.; Sokolove, Jeremy; Weerapana, Eranthie; Thompson, Paul R. (2015-11-20)
      Anti-citrullinated protein antibodies (ACPAs) are a hallmark of rheumatoid arthritis (RA) and are routinely used for disease diagnosis. Protein citrullination is also increased in cancer and other autoimmune disorders, ...
    • Citrulination unravels stem cells 

      Slade, Daniel J.; Subramanian, Venkataraman; Thompson, Paul R. (2014-05)
      Maintenance of the pluripotent stem cell state is regulated by the post-translational modification of histones. The discovery that citrullination of the linker histone H1 is critical to this
    • Crystal structure of the MACPF domain of human complement protein C8 alpha in complex with the C8 gamma subunit 

      Slade, Daniel J.; Lovelace, Leslie L.; Chruszcz, Maksymilian; Minor, Wladek; Lebioda, Lukasz; Sodetz, James M. (Academic Press Ltd Elsevier Science Ltd, 2008-05-29)
      Human C8 is one of five complement components (C5b, C6, C7, C8 and C9) that assemble on bacterial membranes to form a pore-like structure referred to as the "membrane attack complex" (MAC). C8 contains three genetically ...
    • Flavin oxidation in flavin dependent N-monooxygenase 

      Sobrado, Pablo; Robinson, Reeder; Klancher, Catherine; Rodriguez, Pedro (2019-01-02)
    • Fluorescence Polarization Binding Assay for Aspergillus fumigatus Virulence Factor UDP-Galactopyranose Mutase 

      Qi, Jun; Oppenheimer, Michelle; Sobrado, Pablo (Hindawi, 2011-08-21)
      Aspergillus fumigatus is an opportunistic human pathogenic fungus responsible for deadly lung infections in immunocompromised individuals. Galactofuranose (Galf) residues are essential components of the cell wall and play ...
    • Genetic Reporter System for Positioning of Proteins at the Bacterial Pole 

      Fixen, Kathryn R.; Janakiraman, Anuradha; Garrity, Sean; Slade, Daniel J.; Gray, Andrew N.; Karahan, Nilay; Hochschild, Ann; Goldberg, Marcia B. (2012)
      Spatial organization within bacteria is fundamental to many cellular processes, although the basic mechanisms underlying localization of proteins to specific sites within bacteria are poorly understood. The study of protein ...
    • HIV-1 drug discovery: targeting folded RNA structures with branched peptides 

      Wynn, Jessica E.; Santos, Webster L. (The Royal Society of Chemistry, 2015-04-28)
      Human immunodeficiency virus type 1 (HIV-1) is an RNA virus that is prone to high rates of mutation. While the disease is managed with current antiretroviral therapies, drugs with a new mode of action are needed. A strategy ...
    • Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane 

      Kenwood, Brandon M.; Weaver, Janelle L.; Bajwa, Amandeep; Poon, Ivan K.; Byrne, Frances L.; Murrow, Beverley A.; Calderone, Joseph A.; Huang, Liping; Divakaruni, Ajit S.; Tomsig, Jose L.; Okabe, Kohki; Lo, Ryan H.; Coleman, G. Cameron; Columbus, Linda; Yan, Zhen; Saucerman, Jeffrey J.; Smith, Jeffrey S.; Holmes, Jeffrey W.; Lynch, Kevin R.; Ravichandran, Kodi S.; Uchiyama, Seiichi; Santos, Webster L.; Rogers, George W.; Okusa, Mark D.; Bayliss, Douglas A.; Hoehn, Kyle L. (Elsevier, 2013)
      Dysregulation of oxidative phosphorylation is associated with increased mitochondrial reactive oxygen species production and some of the most prevalent human diseases including obesity, cancer, diabetes, neurodegeneration, ...
    • Identification of Aspergillus fumigatus UDP-Galactopyranose Mutase Inhibitors 

      del Campo, Julia S. Martin; Eckshtain-Levi, Meital; Vogelaar, Nancy J.; Sobrado, Pablo (Nature, 2017-09-07)
      Aspergillus fumigatus is an opportunistic human pathogen responsible for deadly, invasive infections in immunocompromised patients. The A. fumigatus cell wall is a complex network of polysaccharides among them galactofuran, ...
    • Inhibiting neurotransmitter reuptake 

      Chemistry; Center for Drug Discovery; Virginia Tech Intellectual Properties, Inc.; Mayo Foundation for Medical Edication and Research; Carlier, Paul R.; Richelson, Elliott; Fauq, Abdul H.; Monceaux, Christopher J. (United States Patent and Trademark Office, 2018-04-17)
      This document relates to compounds as well as methods and materials involved in modulating neurotransmitter reuptake. For example, compounds, methods for synthesizing compounds, and methods for inhibiting neurotransmitter ...
    • Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation. 

      Lewis, Huw D.; Liddle, John; Coote, Jim E.; Atkinson, Stephen J.; Barker, Michael D.; Bax, Benjamin D.; Bicker, Kevin L.; Bingham, Ryan P.; Campbell, Matthew; Chen, Yu Hua; Chung, Chun-wa; Craggs, Peter D.; Davis, Rob P.; Eberhard, Dirk; Joberty, Gerard; Lind, Kenneth E.; Locke, Kelly; Maller, Claire; Martinod, Kimberly; Patten, Chris; Polyakova, Oxana; Rise, Cecil E.; Rüdiger, Martin; Sheppard, Robert J.; Slade, Daniel J.; Thomas, Pamela; Thorpe, Jim; Yao, Gang; Drewes, Gerard; Wagner, Denisa D.; Thompson, Paul R.; Prinjha, Rab K.; Wilson, David M. (2015-03)
      PAD4 has been strongly implicated in the pathogenesis of autoimmune, cardiovascular and oncological diseases through clinical genetics and gene disruption in mice. New selective PAD4 inhibitors binding a calcium-deficient ...
    • Learning Chemistry from Bacteria 

      Clardy, Jon (2013-12-17)
      Dr. Jon Clardy Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Harvard University All animals, including humans, originated and evolved on a planet already teeming with bacteria, and ...
    • Mechanism of sphingosine 1-phosphate clearance from blood 

      Kharel, Yugesh; Huang, Tao; Salamon, Anita; Harris, Thurl E.; Santos, Webster L.; Lynch, Kevin R. (Portland Press, 2020-03-06)
      The interplay of sphingosine 1-phosphate (S1P) synthetic and degradative enzymes as well as S1P exporters creates concentration gradients that are a fundamental to S1P biology. Extracellular S1P levels, such as in blood ...